in silico analysis of molecular interactions between commercially available drugs in Japan and proteins

点击翻译按钮获取中文摘要

Understanding of modes of interactions between drugs and proteins is important to promote drug discovery and studies on side-effects of drugs. Although it is not practically possible to measure all the interactions experimentally, in silico methods are expected to become viable alternatives. In this project, we have studied novel methodologies essential for this purpose, and applied them to evaluate the interactions between commercially available drugs and proteins which are closely related to carbohydrate metabolism.