Analyses of the N-substituted formamide metabolic pathway and their applications to the production of useful compounds
Analyses of the N-substituted formamide metabolic pathway and their applications to the production of useful compounds
批准号:
19208008
负责人:
KOBAYASHI Michihiko
金额:
$31.45万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
To clarify the function of enzymes involved in the N-substituted formamide synthesis/degradation, the microorganism with both enzyme activities was analyzed. Isonitrile hydratase was purified and characterize. The enzyme was found to be a new type of isonitrile hydratase. Reverse reaction of N-substituted formamide deformylase was found and the reaction mechanism was proposed. Some compounds were produced using the reverse reaction the enzyme.
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放線菌のN-置換ホルムアミド分解酵素の逆反応解析
放线菌N-取代甲酰胺降解酶的逆反应分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[坂下俊秀, 深津寛, 橋本義輝, 小林達彦]
通讯作者:
小林達彦
Unique function of the enzyme involved in isonitrile metablism-A new synthetic route to N-benzylamides-
异腈代谢酶的独特功能-N-苯甲酰胺的新合成路线-
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[M. Kobayashi, T. Sakashita, H. Fukatsu, and Y. Hashimoto]
通讯作者:
and Y. Hashimoto
イソニトリル・ニトリルの新規代謝経路の発見と新規酵素の分子機能解析
异腈和腈新代谢途径的发现及新酶的分子功能分析
DOI:
--
发表时间:
2007
期刊:
生化学
影响因子:
--
作者:
[Suzuki, M., Tseeb, V., Oyama, K., Iwai, K., Ishiwata, S., 長谷川利拡, ○村上 聡, 橋本義輝]
通讯作者:
橋本義輝
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[M. Kobayashi, M. Goda, H. Fukatsu and Y. Hashimoto]
通讯作者:
H. Fukatsu and Y. Hashimoto
Novel isonitrile hydratase involved in isonitrile metabolism
参与异腈代谢的新型异腈水合酶
DOI:
--
发表时间:
2010
期刊:
J. Biol. Chem
影响因子:
--
作者:
[Sato, H., Hashimoto, Y., Fukatsu, H. and Kobayashi, M]
通讯作者:
M
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