Preparation of Non-spherical Cell-containing Hydrogel Materials Using Microscale Aqueous Multi-phase Systems

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Microfluidic techniques have been developed to prepare non-spherical hydrogel materials utilizing multiphase laminar flows inside microchannels. By mainly using alginate as the hydrogel substrate, we fabricated anisotropic hydrogel fibers with the cross section composed of multiple regions of different compositions, and non-spherical yarn-ball-shape hydrogel beads having a large surface-to-volume ratio. As applications, we successfully performed the guided cell growth and high-density cell cultivation, demonstrating the usefulness of the presented hydrogel materials.