Effect of muscle derived protein on energy metabolism

肌肉来源的蛋白质对能量代谢的影响

• 批准号: 21800045
• 负责人: TANIMURA Yuko
• 金额: $ 1.44万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21800045/
• 关键词: エネルギー代謝; 持久性運動; FGF21; 運動; 運動トレーニング

Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator and improves glucose and lipid metabolism. FGF21 is produced and secreted by liver, adipose, and skeletal muscle. The aim of present study is to examine whether skeletalmuscle derived FGF21 is regulated by exercise, so that we can elucidate the mechanismof the effect of exercise on lifestyle disease. Serum FGF21 significantly increased afteracute exercise in young health males, as well as in human after acute exercise. In addition,FGF21 mRNA and protein expression in skeletal muscle of mice also significantly increaseafter acute exercise. These data indicate that muscle-derived FGF21 may be a candidateto explain the beneficial effects of exercise.

成纤维细胞生长因子21 （Fibroblast growth factor 21, FGF21）是一种新型的代谢调节剂，可改善糖脂代谢。FGF21由肝脏、脂肪和骨骼肌产生和分泌。本研究旨在探讨运动是否调节骨骼肌来源的FGF21，从而阐明运动对生活方式疾病的影响机制。年轻健康男性急性运动后血清FGF21显著升高，人体急性运动后血清FGF21也显著升高。此外，急性运动后小鼠骨骼肌中FGF21 mRNA和蛋白的表达也显著增加。这些数据表明，肌肉来源的FGF21可能是解释运动有益作用的候选因子。

项目成果

Circulating Fibroblast Growth Factor 21 is induced by acute exercise in young sedentary males.

年轻久坐男性的剧烈运动会诱导循环成纤维细胞生长因子 21。

• 发表时间: 2010
• 作者: Yuko Tanimura;Wataru Aoi;Yoshikazu Takanami;Yukari Kawai;Ryuichi Ajisaka;Toshikazu Yoshikawa
• 通讯作者: Toshikazu Yoshikawa