Effect of muscle derived protein on energy metabolism

成纤维细胞生长因子21(FGF21)是一种新型的代谢调节剂，可改善糖脂代谢。FGF21由肝脏、脂肪和骨骼肌产生和分泌。本研究旨在探讨骨骼肌源性FGF21是否受运动的调节，从而阐明运动对生活方式疾病的影响机制。健康青年男性急性运动后血清FGF21显著升高，人类急性运动后血清FGF21也显著升高。此外，急性运动后小鼠骨骼肌中FGF21mRNA和蛋白的表达也显著增加。这些数据表明，肌肉来源的FGF21可能是解释运动有益效果的候选基因。

Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator and improves glucose and lipid metabolism. FGF21 is produced and secreted by liver, adipose, and skeletal muscle. The aim of present study is to examine whether skeletalmuscle derived FGF21 is regulated by exercise, so that we can elucidate the mechanismof the effect of exercise on lifestyle disease. Serum FGF21 significantly increased afteracute exercise in young health males, as well as in human after acute exercise. In addition,FGF21 mRNA and protein expression in skeletal muscle of mice also significantly increaseafter acute exercise. These data indicate that muscle-derived FGF21 may be a candidateto explain the beneficial effects of exercise.