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Biomechanical regulation of cell shape, proliferation and cell death

Biomechanical regulation of cell shape, proliferation and cell death
细胞形状、增殖和细胞死亡的生物力学调节
批准号:
21870040
负责人:
HAYASHI Takashi
金额:
$1.76万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
翻译
以果蝇(Drosophilamelanogaster)为模型系统,研究了生物力学在细胞形态控制、增殖和死亡中的作用。通过研究在体内操纵Rho、Rac或非肌肉肌球蛋白的功能的效果,已经表明细胞的形状受细胞骨架产生的表面张力的控制。建立了一套研究生物力学对细胞增殖或死亡作用的实验系统。
英文摘要
The roles of biomechanics on cell shape control, proliferation and cell death were studied using Drosophila melanogaster as the model system. It has been shown that the shape of cells is under the control of surface tension, which is produced by cytoskeletons, by studying the effects of manipulating the function of Rho, Rac or non-muscle Myosin in vivo. An experimental system for studying the roles of biomechanics on proliferation or cell death has also been established.
期刊论文(3)
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科研奖励(0)
会议论文
DOI: --
发表时间: 2009
期刊: 生物物理 Vol.49、No.6
影响因子: --
作者: [Motoki Takaku, Takashi Kainuma, Takako Ishida-Takaku, et al., 林貴史]
通讯作者: 林貴史
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
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    16K07078
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relative size regulation in the developing organism
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海外基金