Identification of the regulatory factor for insect-form transformation of trypanosomes from tsetse flies

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To control the African Sleeping Sickness, which is caused by the infection of trypanosome parasites (Trypanosoma spp.) into mammalian blood, it is required to understand the regulatory mechanisms for cell differentiation into insect form parasite at the timing of infection. In this study, the full length of Glossina serine protease 1 (Gsp1) was isolated by RACE PCR as the candidate of regulatory molecules, and it was showed that Gsp1 have the trypsin-like serine protease domain. Considering the previous studies, one of the serine protease genes duplicated might gain the novel function for controlling the insect-form transformation of Trypanosoma. I