Epidemiological and molecular investigation on prevalence of antimicrobial resistance in Escherichia coli isolates from pups, diseased dogs, and humans.

对幼犬、病犬和人类大肠杆菌中抗菌药物耐药性流行率的流行病学和分子研究。

• 批准号: 21880043
• 负责人: HARADA Kazuki
• 金额: $ 1.03万
• 依托单位: Nippon Veterinary and Life Science University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21880043/
• 关键词: 大腸菌; 薬剤耐性; 犬; ヒト; 病原因子; クローン; 疫学; 遺伝子; ESBL; 抗生物質; 細菌

In this study, I investigated prevalence of antimicrobial resistance and their relative factors in Escherichia coli isolates from dogs and humans. Pup-origin isolates spread clonally in each kennel, resulting in different prevalence of resistance between kennels. In addition, resistance prevalence was associated with virulence factors and phylogenetic groups in dogs with urogenital infections. Furthermore, virulence factors, but not antimicrobial resistance, was more prevalent in canine isolates than in owner isolates, and genetic analysis revealed clone sharing between dogs and their owners.

在这项研究中，我研究了抗菌素耐药性及其在狗和人类大肠杆菌分离株中的相对因素的患病率。幼崽 - 幼虫分离株在每个狗窝中散布，导致狗窝之间的抗药性患病率不同。另外，抗药性因子与泌尿生殖器感染的狗的毒力因子和系统发育群有关。此外，毒力因素（而不是抗菌素的抗性）在犬分离株中比在所有者分离株中更为普遍，遗传分析揭示了狗与其所有者之间的克隆共享。

项目成果

Clonal spread of antimicrobial-resistant Eschericbia coli isolates among pups in two kennels.

两个犬舍中的幼犬中耐药大肠杆菌分离株的克隆传播。

• 发表时间: 2011
• 期刊: Acta Veterinaria Scandinavica
• 影响因子: 2.1
• 作者: Harada;K.;Morimoto;E.;Kataoka;Y.;Takahashi;T.
• 通讯作者: T.

Prevalence of antimicrobial resistance in relation to virulence genes and phylogenetic origins among urogenital Eschericbia coil isolates from dogs and cats in Japan.

日本狗和猫泌尿生殖道大肠杆菌分离株中与毒力基因和系统发育起源相关的抗菌药物耐药性的流行。

• 期刊: American Journal of Veterinary Research
• 影响因子: 1
• 作者: Harada;K.;Niina;A.;Nakai;Y.;Kataoka;Y.;Takahashi;T.
• 通讯作者: T.

Clonal spread of antimicrobial-resistant Escherichia coli isolates among pups in two kennels

• DOI: 10.1186/1751-0147-53-11
• 发表时间: 2011-02-17
• 期刊: ACTA VETERINARIA SCANDINAVICA
• 影响因子: 2.1
• 作者: Harada, Kazuki;Morimoto, Erika;Takahashi, Toshio
• 通讯作者: Takahashi, Toshio

Prevalence of antimicrobial resistance in relation to virulence genes and phylogenetic origins among urogenital Escherichia coli isolates from dogs and cats in Japan

• DOI: 10.2460/ajvr.73.3.409
• 发表时间: 2012-03-01
• 期刊: AMERICAN JOURNAL OF VETERINARY RESEARCH
• 影响因子: 1
• 作者: Harada, Kazuki;Niina, Ayaka;Takahashi, Toshio
• 通讯作者: Takahashi, Toshio

犬の泌尿生殖器疾患由来大腸菌の病原性因子の保有状況調査と薬剤耐性分布との関係解析

犬泌尿生殖道疾病大肠杆菌毒力因子流行情况调查及与耐药性分布的关系分析

• 发表时间: 2010
• 作者: 新名彩加;中井悠華;原田和記;片岡康;高橋敏雄
• 通讯作者: 高橋敏雄