Development of New Antiviral Therapy Targeting Viroporins

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Viroporins are a group of proteins interact with cellular membranes modifying permeability and which participate in the promotion of release of viral particles from infected cells. The JCV encoded agnoprotein, which is recognized as a viroporin recently, is essential for the viral replication. Here, we demonstrate that JCV viroporin, agnoprotein, interacts with the delta subunit of AP-3. This interaction prevents AP-3-mediated intracellular vesicular trafficking, resulting in plasma membrane permeabilization and facilitating virion release. Furthermore, the disruption of this interaction repressed both the viroporin activity and JC virus replication.