Developing a novel therapy with umbilical cord blood cells for perinatal brain injuries

开发新的治疗围产期新生儿缺氧缺血性脑病(HIE)的方法是当务之急。在本项目中，我们进行了基础实验，以开发一种新的治疗方法-人脐血细胞，这是围产期脑损伤最理想的干细胞来源。建立围产期HIE大鼠模型，观察HUCB对围产期HIE的影响。我们在缺氧缺血性损伤后给予HUSB腹腔注射。注射后的HUSB向脑内迁移，倾向于发挥抗细胞凋亡和抗氧化作用，促进细胞增殖。

It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we have performed basic experiments for developing a novel therapy with human umbilical cord blood cells (HUCB), which is most ideal source of stem cells for perinatal brain injuries. After establishing a perinatal HI rat model, we evaluated the effect of administration of HUCB on perinatal HIE. We injected HUSB peritoneally after hypoxic-ischemic insult. The injected HUSB migrated into the brain, and tended to exert the anti-apoptotic and anti-oxidative effect, and increase the cell proliferation.