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Antiapoptotic effect of glutaredoxin in myocardiac cellsb induced by regulationg the redox state of GAPDH.

Antiapoptotic effect of glutaredoxin in myocardiac cellsb induced by regulationg the redox state of GAPDH.
谷氧还蛋白通过调节 GAPDH 的氧化还原状态诱导心肌细胞 b 的抗凋亡作用。
批准号：
21890193
负责人：
INADOMI Chiaki
金额：
$1.66万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Research Activity Start-up
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2010
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890193/
关键词：
酸化ストレス心筋保護循環器・高血圧

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英文摘要
It is known that NO induced S-nitrosylation of GAPDH elicits its nuclear translocation and causes apoptotic cell death. In H9c2-control cells, NO-induced cell death increased dose-dependently compare to GRX1-overexpressed rat myocardiac H9c2 cells(H9c2-GRX). We revealed that GRX1 suppressed S-nitrosylation of GAPDH in H9c2-GRX. In addition, NO-induced nuclear translocation of GAPDH was decreased in H9c2-GRX compared to H9c2 control cells. These data suggest that GRX exerts the antiapoptotic effect by suppressing the S-nitrosylation of GAPDH.
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The effect of hyperoxygenation on stem cell mobilization and ischemia/reperfusion injury.
  • 批准号：
    26462339
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.16万
  • 财政年份：
    2014
  • 负责人：
    INADOMI Chiaki
  • 依托单位：
    Nagasaki University
Antiapoptotic effect of glutaredoxin in cardiomyocytes by inducing changes in the cellular redox system.
  • 批准号：
    23791715
  • 项目类别：
    Grant-in-Aid for Young Scientists (B)
  • 资助金额：
    $2.66万
  • 财政年份：
    2011
  • 负责人：
    INADOMI Chiaki
  • 依托单位：
    Nagasaki University
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