Epigenetics analysis in abnormal behavior through dopamin receptors

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In this study, we demonstrated that pre-treatment with fluoxetine, an SSRIs, significantly suppressed L-DOPA-induced ERK1/2 and histone H3 phosphorylation, as well as L-DOPA-induced rotational behavior in 6-OHDA-lesioned rats. These data indicate that L-DOPA-derived DA, released as a "false transmitter" from 5-HT terminals, enhances levels of phosphorylated ERK and histone H3, and this results in abnormal behavior. Fluoxetine may attenuate these effects of a false transmitter via 5-HT receptor. In further support of this supposition, these effects of fluoxetine were abolished by pre-treatment with WAY 100135, a 5-HT1A antagonist.These results suggest that fluoxetine may influence motor function in PD via pharmacological modification of interactions between serotonergic and dopaminergic neuronal networks.