Genetic polymorphisms of antioxidant enzymes and colorectal carcinogenesis

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Oxidative stress causes DNA damage and may be involved in carcinogenesis. Endogenous antioxidant enzymes are known to be defensive against oxidative stress. To clarify the influence of the oxidative stress on colorectal carcinogenesis, we investigated the relation of functional genetic polymorphisms of manganese superoxide dismutase, catalase, and glutathione peroxidase to colorectal adenomas and cancer. None of the polymorphisms under study showed a measurable association with colorectal adenoma risk. A statistically significant decrease in the risk of colorectal cancer was observed among those with the T allele of CAT-262C>T.