Search for Proteomics-based analysis of non-alcoholic fatty liver diseases (NAFLD/NASH) in mice.

搜索基于蛋白质组学的小鼠非酒精性脂肪肝疾病 (NAFLD/NASH) 分析。

• 批准号: 21890318
• 负责人: NAGANO Kazuya
• 金额: $ 1.7万
• 依托单位: National Institute of Biomedical Innovation
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890318/
• 关键词: メタボリックシンドローム; Non-alcoholic steatohepatitis(NASH); Non-alcoholic fatty liver disease(NAFLD); バイオマーカー; NAFLD; NASH; 抗体プロテオミクス技術

It has been estimated that non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD), early stage of NASH, become main factors to cause liver cancer and hepatic cirrhosis in future. Therefore, development of diagnostic and therapeutic techniques is urgently needed. However these diseases are hardly known, due to having been recently recognized. In this study, we searched for NAFLD-related proteins and resulted in successfully identifying 8 kinds of candidate proteins more highly expressed in liver of NAFALD model mice.

据估计，非酒精性脂肪性肝炎（NASH）和非酒精性脂肪性肝病（NAFLD）作为NASH的早期阶段，在未来将成为导致肝癌和肝硬化的主要因素。因此，迫切需要发展诊断和治疗技术。然而，由于最近才被认识到，这些疾病几乎不为人所知。在本研究中，我们对nafld相关蛋白进行了搜索，成功鉴定出8种在NAFALD模型小鼠肝脏中表达较高的候选蛋白。

项目成果

Proteomics-based analysis of non-alcoholic fatty liver disease (NAFLD) in mice

基于蛋白质组学的小鼠非酒精性脂肪肝病 (NAFLD) 分析

• 发表时间: 2010
• 作者: Watanabe T.;Yamashita T.;Nagano K.;Kanasaki S.;Yoshikawa T.;Yoshioka Y.;Itoh N.;Abe Y.;Kamada H.;Tsutsumi Y.;Tsunoda S.
• 通讯作者: Tsunoda S.

プロテオミクスによる非アルコール性脂肪性肝疾患(NAFLD/NASH)のバイオマーカー探索

使用蛋白质组学搜索非酒精性脂肪性肝病 (NAFLD/NASH) 的生物标志物

• 发表时间: 2010
• 作者: 渡邉貴信;長野一也;山下琢矢;岡村賢孝;金崎聡一郎;阿部康弘;吉川友章;吉岡靖雄;鎌田春彦;伊藤徳夫;小泉桂一;角田慎一;堤康央
• 通讯作者: 堤康央

Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung.

• DOI: 10.1016/j.bbrc.2011.01.077
• 发表时间: 2011-02
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Y. Yoshida;T. Yamashita;K. Nagano;S. Imai;H. Nabeshi;T. Yoshikawa;Y. Yoshioka;Y. Abe;H. Kamada;Y. Tsutsumi;S. Tsunoda

Development of a novel antibody proteomics system using a phage antibody library for efficient screening of tumor-related biomarker proteins.

使用噬菌体抗体库开发新型抗体蛋白质组学系统，用于有效筛选肿瘤相关生物标志物蛋白质。

• 发表时间: 2011
• 期刊: Biomaterials 32(1)
• 作者: Imai S.;Nagano K.;Yoshida Y.;Okamura T.;Yamashita T.;Abe Y.;Yoshikawa T.;Yoshioka Y.;Kamada H.;Mukai Y.;Nakagawa S.;Tsutsumi Y.;Tsunoda S.
• 通讯作者: Tsunoda S.

Development of a novel antibody proteomics system using a phase antibody library for efficient screening of tumor-related biomarker proteins.

使用相抗体库开发新型抗体蛋白质组学系统，用于有效筛选肿瘤相关生物标志物蛋白质。

• 发表时间: 2011
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Imai S.;Nagano K.;Yoshida Y.;Okamura T.;Yamashita T.;Abe Y.;Yoshikawa T.;Yoshioka Y.;Kamada H.;Mukai Y.;Nakagawa S.;Tsutsumi Y.;Tsunoda S.
• 通讯作者: Tsunoda S.