Inter Organ Crosstalk in Non-Alcoholic Steatohepatitis (NASH)

非酒精性脂肪性肝炎 (NASH) 中的器官间串扰

• 批准号: 10391775
• 负责人: Thale Cross Jarvis
• 金额: $ 1.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-08 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391775
• 关键词: Academia; Adipose tissue; Automobile Driving; Biology; Biotechnology; Carcinoma; Cells; Clinical; Collaborations; Colorado; Communication; Complex; Development; Diagnosis; Diagnostic; Discipline; Educational workshop; Endocrine Glands; Energy Metabolism; Fibrosis; Health; Hepatocyte; Human; Industrialization; Inflammation; Interdisciplinary Study; Knowledge; Learning; Lipids; Liver Cirrhosis; Metabolic; Metabolism; Methodology; Microbiology; Muscle; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity Epidemic; Organ; Organoids; Outcome; Pathogenesis; Physiological; Primary carcinoma of the liver cells; Proteomics; Research; Research Personnel; Scientist; Signal Pathway; T-Lymphocyte; Therapeutic; Tissues; Work; base; body system; cell type; clinical practice; gut microbiome; insight; interest; macrophage; meetings; next generation; non-alcoholic fatty liver disease; nonalcoholic steatohepatitis; novel; posters; programs; single-cell RNA sequencing; stellate cell; symposium; targeted treatment; treatment strategy

ABSTRACT Support is requested for a Keystone Symposia conference entitled Inter Organ Crosstalk in Non-Alcoholic Steatohepatitis (NASH), organized by Drs. Greg Steinberg, Camilla Charlotte Schéele and Saswata Talukdar. The conference will be held in Keystone, Colorado from February 6-9, 2022. The epidemics of obesity and type 2 diabetes are driving the development of non-alcoholic steatohepatitis (NASH) which is rapidly accelerating rates of liver cirrhosis and hepatocellar carcinoma (HCC). NASH is characterized by complex crosstalk between different cell types and organ systems that leads to steatosis, inflammation and fibrosis. This intracellular communication involves multiple cells types within the microenvironment (e.g., stellate cells, macrophages, T cells and hepatocytes) but also includes interactions with multiple organ systems (e.g., gut microbiome, brown/beige/white adipose tissue and muscle). With the development of many new technological advances (e.g., proteomics, single cell RNAseq, and organoids), our understanding of these intricate signaling pathways is rapidly expanding. The conference will bring scientists across different disciplines together to provide a forum for sharing rapidly emerging methodological advances in order to understand the mechanisms by which cells and organ systems communicate, in order to develop new paradigms and therapeutic strategies for the treatment of NASH. Given the importance of adipose tissue as a critical storage depot, an endocrine organ, and a regulator of energy expenditure, this conference will be held jointly with the Keystone Symposia meeting Adipose Tissue and Metabolic Health in order to expand opportunities for interdisciplinary interactions.

摘要 要求支持一次题为“非酒精性疾病中器官间串扰”的Keystone研讨会会议。 脂肪性肝炎（NASH），由Greg Steinberg，Camilla夏洛特Schéele和Saswata Talukdar博士组织。 会议将于2022年2月6日至9日在科罗拉多的Keystone举行。 肥胖和2型糖尿病的流行正在推动非酒精性脂肪性肝炎的发展 （NASH）正在迅速加速肝硬化和肝细胞癌（HCC）的发病率。NASH是 其特征在于导致脂肪变性的不同细胞类型和器官系统之间的复杂串扰， 炎症和纤维化。这种细胞内通讯涉及细胞内的多种细胞类型。 微环境（例如，星状细胞、巨噬细胞、T细胞和肝细胞），但也包括相互作用 具有多个器官系统（例如，肠道微生物组、棕色/米色/白色脂肪组织和肌肉）。与 许多新技术进步的发展（例如，蛋白质组学、单细胞RNAseq和类器官），我们的 对这些复杂的信号通路的理解正在迅速扩展。会议将邀请科学家 为分享快速出现的方法学进展提供一个论坛 为了了解细胞和器官系统交流的机制， 治疗NASH的新范例和治疗策略。考虑到脂肪组织的重要性 作为一个重要的储存库，一个内分泌器官，和能量消耗的调节器，这次会议将是 与Keystone研讨会会议脂肪组织和代谢健康联合举行，以扩大 跨学科互动的机会。