Imaging of immune cell dynamics and host-pathogen interactions in gut-associated lymphoid tissue during Yersinia pseudotuberculosis infections (C07)

假结核耶尔森菌感染期间肠道相关淋巴组织中免疫细胞动态和宿主-病原体相互作用的成像（C07）

• 批准号: 452347294
• 金额: --
• 依托单位: Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/452347294?language=en
• 关键词: Imaging; immune; cell; dynamics; host

In order to obtain a high spatio-temporal resolution of the infection process of the gut pathogen Yersinia pseudotuberculosis, we will image the recruitment and dynamics of immune cell populations and characterize Yersinia-targeted immune cells in infected lymphoid tissue of mice during the entire course of the infection. In this context, we will also analyse the role of platelets for neutrophil recruitment and address different neutrophil functions, including NET formation, and how they are manipulated by bacterial evasion mechanisms.

为了获得肠道病原体假结核耶尔森菌感染过程的高时空分辨率，我们将成像免疫细胞群的招募和动态，并在感染的整个过程中表征受感染的小鼠淋巴组织中的耶尔森氏菌靶向免疫细胞。在此背景下，我们还将分析血小板在中性粒细胞募集中的作用，并讨论不同的中性粒细胞功能，包括网络形成，以及它们是如何被细菌逃避机制操纵的。