Regulation of CNS Lupus by brain macrophages (B18*)

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CNS Lupus is a clinical entity that includes conditions as diverse as cognitive dysfunction andpsychosis. Diagnosing CNS lupus is challenging and treatment options are limited. Despite theseunmet clinical needs, our knowledge of its pathogenesis is scarce. Here, we aim to shed light to therole of type I interferons, microglia and CNS- associated macrophages in the pathogenesis of CNSlupus at single cell resolution. Our goal is to uncover basic pathogenetic principles underlying thespectrum of clinical presentations of neuropsychiatric lupus and thus identify new diagnostic tools andtreatment targets.