Regulation of CNS Lupus by brain macrophages (B18*)

脑巨噬细胞 (B18*) 对中枢神经系统狼疮的调节

• 批准号: 452451365
• 金额: --
• 依托单位: Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie (einschließlich Arbeitsbereich Physikalische Medizin)
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/452451365?language=en
• 关键词: Regulation; CNS; Lupus; brain; macrophages

CNS Lupus is a clinical entity that includes conditions as diverse as cognitive dysfunction andpsychosis. Diagnosing CNS lupus is challenging and treatment options are limited. Despite theseunmet clinical needs, our knowledge of its pathogenesis is scarce. Here, we aim to shed light to therole of type I interferons, microglia and CNS- associated macrophages in the pathogenesis of CNSlupus at single cell resolution. Our goal is to uncover basic pathogenetic principles underlying thespectrum of clinical presentations of neuropsychiatric lupus and thus identify new diagnostic tools andtreatment targets.

中枢神经系统狼疮是一种临床实体，包括认知功能障碍和精神病等多种疾病。诊断中枢神经系统狼疮具有挑战性，治疗选择有限。尽管临床需求未得到满足，但我们对其发病机制的了解却很少。在此，我们的目标是阐明I型干扰素、小胶质细胞和CNS相关巨噬细胞在单细胞分辨率下的CN Slupus发病机制中的作用。我们的目标是揭示神经精神狼疮临床表现谱的基本发病机制，从而确定新的诊断工具和治疗靶点。