The role of reactive oxygen and nitrogen species in rheumatoid arthritis-induced skeletal muscle dysfunction.
The role of reactive oxygen and nitrogen species in rheumatoid arthritis-induced skeletal muscle dysfunction.
批准号:
22800051
负责人:
YAMADA Takashi
金额:
$2.01万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Peroxynitrite anion(ONOO^-) has been proposed to be one of the principal causes of the muscle wasting and weakness observed in rheumatoid arthritis. However, the biological effects of ONOO^-on skeletal muscle remains poorly understood. The present study investigated the effects of ONOO^-donor 3-morpholinosynonimine(SIN-1) on the contractile properties of intact fibres from a mouse foot muscle. Our results suggest that ONOO^-induces the skeletal muscle dysfunction due to an irreversible oxidation of sarcoplasmic reticulum Ca^<2+> release channels.
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DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Westerblad, H., Place, N. and Yamada, T.]
通讯作者:
T.
骨格筋を知る-分子レベルから覗く骨格筋研究-7,老化に伴う筋弱化のメカニズム
了解骨骼肌 - 从分子水平研究骨骼肌 - 7、衰老相关肌无力的机制
DOI:
--
发表时间:
2011
期刊:
体育の科学
影响因子:
--
作者:
[J.Ohta, A.Tagawa, T.Kobayashi, T.Noda, K.Sasagawa, T.Tokuda, 山田崇史]
通讯作者:
山田崇史
Mitochondrial production of reactive oxygen species contributes to the{beta}-adrenergic stimulation of mouse cardiomycytes
线粒体产生活性氧有助于小鼠心肌细胞的{β}-肾上腺素能刺激
DOI:
--
发表时间:
2011
期刊:
J. Physiol
影响因子:
--
作者:
[Andersson, DC., Fauconnier, J., Yamada, T., Lacampagne, A., Zhang, SJ., Katz, A. and Westerblad, H.]
通讯作者:
H.
Effects of peroxynitrite on intact, single skeletal muscle fibres from the mouse
过氧亚硝酸盐对小鼠完整、单一骨骼肌纤维的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yamada, T., Ivarsson, N., Kanzaki, K., Kuratani, M., Matsunaga, S., Wada, M., Westerblad, H. and Bruton, JD.]
通讯作者:
JD.
ペルオキシナイトライトがマウスの単一筋線維に及ぼす影響
过氧亚硝酸盐对小鼠单肌纤维的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[山田崇史]
通讯作者:
山田崇史
共 17 条
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Electron Solvation Dynamics in One-Dimensional Superstructures Investigated by Two-Photon Photoemission Spectroscopy
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Studies on self-assembling peptides containing novel amino acids with hetero-rings in side-chains
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Establishment of watershed conservation methodology based on the prediction of biosphere damage due to fine sediment discharge
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Characterization of novel viral enzymes to be utilized in recycling of biomass
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Construction of peptides having molecular recognition ability by using novel α, α-disubstituted glycines
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A Study of Facilitating of Collaboration between Patients and Occupational Therapist
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