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The role of reactive oxygen and nitrogen species in rheumatoid arthritis-induced skeletal muscle dysfunction.

The role of reactive oxygen and nitrogen species in rheumatoid arthritis-induced skeletal muscle dysfunction.
活性氧和氮在类风湿性关节炎引起的骨骼肌功能障碍中的作用。
批准号:
22800051
负责人:
YAMADA Takashi
金额:
$2.01万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
Peroxynitrite anion(ONOO^-) has been proposed to be one of the principal causes of the muscle wasting and weakness observed in rheumatoid arthritis. However, the biological effects of ONOO^-on skeletal muscle remains poorly understood. The present study investigated the effects of ONOO^-donor 3-morpholinosynonimine(SIN-1) on the contractile properties of intact fibres from a mouse foot muscle. Our results suggest that ONOO^-induces the skeletal muscle dysfunction due to an irreversible oxidation of sarcoplasmic reticulum Ca^<2+> release channels.
期刊论文(27)
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会议论文
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Westerblad, H., Place, N. and Yamada, T.]
通讯作者: T.
骨格筋を知る-分子レベルから覗く骨格筋研究-7,老化に伴う筋弱化のメカニズム
了解骨骼肌 - 从分子水平研究骨骼肌 - 7、衰老相关肌无力的机制
DOI: --
发表时间: 2011
期刊: 体育の科学
影响因子: --
作者: [J.Ohta, A.Tagawa, T.Kobayashi, T.Noda, K.Sasagawa, T.Tokuda, 山田崇史]
通讯作者: 山田崇史
Mitochondrial production of reactive oxygen species contributes to the{beta}-adrenergic stimulation of mouse cardiomycytes
线粒体产生活性氧有助于小鼠心肌细胞的{β}-肾上腺素能刺激
DOI: --
发表时间: 2011
期刊: J. Physiol
影响因子: --
作者: [Andersson, DC., Fauconnier, J., Yamada, T., Lacampagne, A., Zhang, SJ., Katz, A. and Westerblad, H.]
通讯作者: H.
Effects of peroxynitrite on intact, single skeletal muscle fibres from the mouse
过氧亚硝酸盐对小鼠完整、单一骨骼肌纤维的影响
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Yamada, T., Ivarsson, N., Kanzaki, K., Kuratani, M., Matsunaga, S., Wada, M., Westerblad, H. and Bruton, JD.]
通讯作者: JD.
17
    Developing and testing of the comprehensive life support program for the elderly dementia:a randomized control trial
    • 批准号:
      17K01528
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2017
    • 负责人:
      YAMADA Takashi
    • 依托单位:
    Study on decision-making and behavior of economic agents in endogeneous and dynamic social and economic systems(Fostering Joint International Research)
    • 批准号:
      15KK0123
    • 项目类别:
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • 资助金额:
      $4.58万
    • 财政年份:
      2016
    • 负责人:
      YAMADA Takashi
    • 依托单位:
    Study on decision-making and behavior of economic agents in endogeneous and dynamic social and economic systems
    • 批准号:
      15K01180
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2015
    • 负责人:
      YAMADA Takashi
    • 依托单位:
    Effect of heat stress on contractile properties of skeletal muscle from adjuvant-induced arthritis rat
    • 批准号:
      24700541
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.91万
    • 财政年份:
      2012
    • 负责人:
      YAMADA Takashi
    • 依托单位:
    海外基金