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The estimation of depression by brain imaging

The estimation of depression by brain imaging
通过脑成像评估抑郁症
批准号:
23700491
负责人:
YAMADA Takashi
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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项目成果

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中文摘要
翻译
在这项研究中,我们评估了PET成像在评估抑郁症方面的有效性,并测量了大脑单胺成分,特别是5-羟色胺转运体。我们利用5-羟色胺转运体配体11C-DASB,获得了不同年龄组大鼠脑内5-羟色胺转运体的图像。提示不同年龄段5-羟色胺转运体的表达不同,通过脑成像可以区分不同年龄段5-羟色胺转运体表达的差异。此外,我们还比较了体力应激大鼠脑内5-羟色胺的含量、转运蛋白的表达水平和脑组织中的转运蛋白表达水平。从这些结果中,我们认为PET成像将是检测脑内5-羟色胺成分和评估抑郁症病情的有效工具。
英文摘要
In this study, we estimated an effectiveness of PET imaging for evaluating depression and we measured brain monoamine component, especially serotonin transporter. We used serotonin transpoter ligand 11C-DASB, abtained rat brain serotonin transporter image by some age group. Then, we suggested empression of serotonin transporter was differ in some age group, and the difference could distinguish by brain imaging. In addition, we compared with brain setoronin transporter image and amount of brain serotonin, transporter expression level in rats which received physical stress. From these results, we suggested that PET imaging would be effectual tool for brain serotonin component and estimating the condition of the depression.
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Measurement of serotonin transporter in rat brain by [11C]DASB - Preliminary study with high resolution animal PET scanner.
通过 [11C]DASB 测量大鼠大脑中的血清素转运蛋白 - 使用高分辨率动物 PET 扫描仪进行初步研究。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Takashi Yamada, Kentaro Hatano, Kengo Ito.]
通讯作者: Kengo Ito.
Developing and testing of the comprehensive life support program for the elderly dementia:a randomized control trial
  • 批准号:
    17K01528
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2017
  • 负责人:
    YAMADA Takashi
  • 依托单位:
Study on decision-making and behavior of economic agents in endogeneous and dynamic social and economic systems(Fostering Joint International Research)
  • 批准号:
    15KK0123
  • 项目类别:
    Fund for the Promotion of Joint International Research (Fostering Joint International Research)
  • 资助金额:
    $4.58万
  • 财政年份:
    2016
  • 负责人:
    YAMADA Takashi
  • 依托单位:
Study on decision-making and behavior of economic agents in endogeneous and dynamic social and economic systems
  • 批准号:
    15K01180
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2015
  • 负责人:
    YAMADA Takashi
  • 依托单位:
Effect of heat stress on contractile properties of skeletal muscle from adjuvant-induced arthritis rat
  • 批准号:
    24700541
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.91万
  • 财政年份:
    2012
  • 负责人:
    YAMADA Takashi
  • 依托单位:
海外基金