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Structure and function of a novel signal transducer protein that employs heme-PAS domain as a sensor

Structure and function of a novel signal transducer protein that employs heme-PAS domain as a sensor
采用血红素-PAS结构域作为传感器的新型信号转导蛋白的结构和功能
批准号:
22870043
负责人:
SAWAI Hitomi
金额:
$2.01万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
I studied the structure and function of Aer2, a novel signal transducer protein for bacterial aerotaxis control. Spectroscopy and site-directed mutagenesis revealed that Aer2 was a new type of oxygen sensor protein employing a heme as a sensor. To elucidate the molecular mechanisms of oxygen sensing and signal transduction, I characterized Aer2 by X-ray crystallography and resonance Raman spectroscopy.
期刊论文(17)
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会议论文
Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginose
铜绿假单胞菌血红素传感器蛋白 Aer2 氧传感和信号转导的结构基础
DOI: --
发表时间: 2012
期刊: Chemical Communications
影响因子: 4.9
作者: [Hitomi Sawai, Hiroshi Sugimoto, Yoshitsugu Shiro, Haruto Ishikawa, Yasuhisa Mizutani, Shigetoshi Aono]
通讯作者: Shigetoshi Aono
ガス分子により駆動される新規なセンサータンパク質の機能発現機構
气体分子驱动的新型传感器蛋白的功能表达机制
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [澤井仁美, 青野重利]
通讯作者: 青野重利
Structural characterization of Aer2 that employs a heme as an oxygen sensor for aerotaxis control
采用血红素作为氧传感器进行趋航性控制的 Aer2 的结构表征
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Hitomi Sawai, Hiroshi Sugimoto, Haruto Ishikawa, Yasuhisa Mizutani, Yoshitsugu Shiro, Shigetoshi Aono]
通讯作者: Shigetoshi Aono
Structural characterization of Aer2 that adopts a heme-containing PAS domain as an oxygen sensor for aerotaxis control
Aer2 的结构表征,采用含血红素的 PAS 域作为氧传感器进行趋航性控制
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Hitomi Sawai, Hiroshi Sugimoto, Haruto Ishikawa, Yoshitsugu Shiro, Yasuhisa Mizutani, Shigetoshi Aono]
通讯作者: Shigetoshi Aono
13
    海外基金