Undersulfation of chondroitin sulfate and abnormal cartilage tissue by the signaling of the receptor of PTH/PTHrP

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The objectives of this study are to elucidate the relationship between not only differentiation of chondrocytes and extracellular matrix, but also proliferation of them. We performed immunohistochemical analysis in cartilage of the spheno-occipital synchondrosis of BALB/c-bm/bm mice. The expression of collagen II and collagen X were expressed irregularly in the spheno-occipital synchondrosis. Additionally, the expression of alkaline phosphatase was expressed in the center of the spheno-occipital synchondrosis, whereas that of the PCNA was expressed around the spheno-occipital synchondrosis. In summary, these results presented that the differentiation of hypertrophic chondrocytes was enhanced in the center of the spheno-occipital synchondrosis, whereas the proliferation of chondrocytes was increased around the spheno-occipital synchondrosis.