Bone regeneration using injectable polyurethane scaffold

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Abstract : We observed morphology of the injectable polyurethane(PUR) scaffold in in vitro using scanning electron microscope, which demonstrated porous structures with interconnected pores. An addition of calcium phosphate(hydroxyapatite, tricalcium phosphate) to PUR resulted in good mechanical property and onsteoconductivity. In vivo injection of PUR also revealed a formation of 3-D porous scaffold, which contributed to repair of bone defects in rat femora. Lovastatin promoted new bone formation in PUR scaffold implanted in the rat femoral bone defects. A combination of injectable PUR and bone anabolic drugs can be useful approach for effective bone regeneration.