Patterns of expression of Kv1. 3 and Kv1. 5 in the mouse brain
Patterns of expression of Kv1. 3 and Kv1. 5 in the mouse brain
批准号:
22890130
负责人:
YAMADA Jun
金额:
$2.01万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
Immunoreactivity for voltage dependent potassium channels Kv1. 3 and Kv1. 5 was not observed in the mouse hippocampus. On the other hand, Kvl. 3 and Kv1. 5 were most highly expressed in microglia after neuronal injuries. Proliferating microglia were not labeled by Kv1. 3/Kv1. 5, but microglia expressing phosphorylated p38 mitogenactivated protein kinase(p-p38 MAPK), markers for neurotoxicity, were Kv1. 3/Kv1. 5positive. Minocyclinetreatment suppressed expression of Kv1. 3/1. 5 and p-p38 MAPK in microglia. These findings suggest that microglia expressing Kv1. 3/1. 5 and p-p38 MAPK can be a potential therapeutic target against neuronal death.
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SlOOA6は活性化アストロサイトと神経幹細胞の選択的マーカーである
SlOOA6 是激活星形胶质细胞和神经干细胞的选择性标记
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[山田純, 神野尚三]
通讯作者:
神野尚三
Differential involvement of astrocytes and microglia in neuronal survival after hypoglossal nerve axotomy. The 29th Naito conference on glia world
星形胶质细胞和小胶质细胞在舌下神经轴索切除术后神经元存活中的差异参与。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamada Jun, Nakanishi Hiroshi, Jinno Shozo.]
通讯作者:
Jinno Shozo.
Alterations in neuronal survival and glial reactions after axotomy by ceftriaxone and minocycline in the mouse hypoglossal nucleus
小鼠舌下核中头孢曲松和米诺环素轴切术后神经元存活和神经胶质反应的改变
DOI:
--
发表时间:
2011
期刊:
Neurosci Lett
影响因子:
2.5
作者:
[Yamada J, Jinno S.]
通讯作者:
Jinno S.
Differential involvement of astrocytes and microglia in neuronal survival after hypoglossal nerve axotomy
星形胶质细胞和小胶质细胞在舌下神经轴索切除术后神经元存活中的差异参与
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yamada Jun, et al]
通讯作者:
et al
全国学術集会
全国学术会议
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[関善弘, 山田純, 神野尚三]
通讯作者:
神野尚三
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