Novel imaging analytical method for measuring the stimulus-induced activity of the cranial nerves

用于测量刺激诱发的脑神经活动的新型成像分析方法

• 批准号: 22890168
• 负责人: KONO Mai
• 金额: $ 1.79万
• 依托单位: Health Sciences University of Hokkaido
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890168/
• 关键词: 脳神経活動; 咀嚼機能; MRI; MEMRI; 咀嚼; 咬合不全; MEMRI信号

In this study, we examined the hypothesis that manganese-enhaced MRI(MEMRI) can detect the effect of physiological and unphysiologocal occlusal force on the behavior of magnesium ion in the brain. As a first step, we investigated the time-dependent change in brain distribution of injected magnesium ion. The high signal intensity was observed in lateral cerebral ventricle and hippocampus at 1 hour post-injection. The signal of magnesium ion was consistently until 6 hours after administration. Next, rats forget for food immediately after administration to examine the effect of chewing on the signal intensity. However, MEMRI can not detect the change in the signal intensity due to the restricted voluntary chewing. It seemed that the toxic side-effect of magnesium reduced food intake and spontaneous activity.

在这项研究中，我们检验了锰增强MRI（MEMRI）可以检测生理性和非生理性咬合力对大脑中镁离子行为的影响的假设。作为第一步，我们研究了注射镁离子在大脑分布的时间依赖性变化。注射后1小时，在侧脑室和海马区观察到高信号强度。镁离子信号持续到给药后6小时。接下来，老鼠在给药后立即忘记食物，以检查咀嚼对信号强度的影响。然而，MEMRI无法检测到由于自主咀嚼受限导致的信号强度变化。镁的毒副作用似乎减少了食物摄入量和自发活动。

项目成果

咀嚼刺激による脳内活動部位検出のための脳機能イメージング法の検討

利用咀嚼刺激检测大脑活动区域的脑功能成像方法研究

• 发表时间: 2012
• 作者: 河野舞;川西克弥;會田英紀;豊下祥史;越野寿
• 通讯作者: 越野寿

咀嚼刺激による脳神経活動部位検出のための脳機能イメージング法の検討

利用咀嚼刺激检测脑神经活动区域的脑功能成像方法研究

• 发表时间: 2012
• 作者: Kawaguchi M;Takahashi M;Hata T;Kashima Y;Usui F;Morimoto H;Izawa A;Takahashi Y;Masumoto J;Koyama J;Hongo M;Noda T;Nakayama J;Sagara J;Taniguchi S;Ikeda U.;鳴海新介;河野舞
• 通讯作者: 河野舞