Screening and elucidation of an allergic exacerbation-barrier disruption action substance in environment and food

上皮细胞包围哺乳动物器官和组织，上皮细胞片构成细胞摄取和转运的主要屏障。紧密连接（TJ）作为限制各种物质（如病原体、毒素和过敏原）的屏障起着关键作用。本研究从环境和食品中筛选出破坏屏障功能和干扰免疫系统的化学物质。结果表明，各种环境污染物均降低了TJ的屏障功能.此外，我们观察到，用二恶英和抗原处理小鼠导致抗原特异性免疫球蛋白产生以剂量依赖性方式显著升高。提示环境和食物中的化学物质可引起屏障功能和免疫系统的失调。

Epithelial cells surround mammalian organs and tissues and epithelial cell sheets constitute the principal barrier to cellular uptake and transport. The tight junction(TJ) plays a pivotal role as both a barrier to restrict various substances, such as pathogens, toxins, and allergens. In this study, we screened the chemical substances to disruption of barrier function and disturbance of immune system in environment and food. It was observed that various environmental pollutants were decreased barrier function of TJ. Furthermore, we observed that treatment of mice with dioxins and antigen results in significant elevation antigen-specific immunoglobulin production in a dose-dependent manner. There results suggest the chemical substance in environment and food dysregulates the barrier function and immune system.