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脳形態学的変化から捉える感覚機能と認知機能低下の相互作用：長期縦断疫学研究

从大脑形态变化看出感觉功能与认知能力下降之间的相互作用：一项长期纵向流行病学研究

基本信息

批准号：
22H00497
负责人：
大塚礼
金额：
$ 27.12万
依托单位：
National Center for Geriatrics and Gerontology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2022
资助国家：
日本
起止时间：
2022-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22H00497/
关键词：
脳形態感覚機能認知機能地域住民縦断研究

项目摘要

視聴覚を含む感覚機能の低下は認知症の危険因子と考えられているが、その病態メカニズムは明らかでない。本研究では地域から性・年齢別に層化無作為抽出された中高年者約2,000名の視聴覚・体性感覚機能、頭部MRI3次元画像、生活習慣および認知機能を14年以上追跡した長期縦断データと血液バイオマーカー測定値をもとに、感覚機能低下と認知機能低下の介在因子を縦断的に明らかにする。2022年度は調査計画立案と倫理審査、国立長寿医療研究センター病院・研究所各部署との調整を経て、2023年2月に「国立長寿医療研究センター・老化に関する長期縦断疫学研究（NILS-LSA）」第10次調査を開始した。第10次調査では、第1次調査から第7次調査参加者のうち、死亡や転出、脱落者を除外し、調査参加への同意が得られた者（見込約2,000名）について、施設内3テスラMRI（Siemens製）による頭部3次元T1・T2/FLAIR画像撮影、視聴覚・体性感覚機能、認知機能、身体機能、社会的活動を含む生活習慣や既往歴を問う調査を実施中である。またナショナルセンター・バイオバンク事業への同意が得られた者について採血を実施し、生化学的検査を行うとともに、血漿・血清のバンキングを進めている。2022年度は、1日2名の調査を週4日行い、年度内に41人の調査を完了し、調査結果の返却等を実施した。上記の調査遂行と並行して、既存データを使用し、視聴覚・体性感覚機能の加齢変化や各種生活習慣要因と脳形態学的変化との縦断的関連について解析を進め、研究成果を公表した。

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