Fundamental understanding of phenylpropanoid, lignin and flavonoid biosynthesis regulated by metabolon formation in grasses for precise manipulation to improve biomass utility

拟议的研究旨在了解苯丙烷类，木质素和类黄酮生物合成酶的代谢子（蛋白质-蛋白质相互作用网络）的全球组织，以水稻为模型，并阐明代谢子的形成如何控制苯丙烷类，木质素和类黄酮生物合成中的代谢通道。通过计算机模拟分析，鉴定了水稻木质素、类黄酮和苯丙素生物合成途径中所有已知和推测的酶。拟议的实验目前正在进行中。

The proposed research is aimed to understand the global organization of metabolons (protein-protein interaction networks) of phenylpropanoid, lignin and flavonoid biosynthetic enzymes that governs metabolite channelling and crosstalk between these pathways in grasses using rice as a model, and to elucidate how metabolon formation controls metabolic channeling in phenylpropanoid, lignin and flavonoid biosynthesis. Through in silico analysis, all the putative and known enzymes in the lignin, flavonoid and phenylpropanoid biosynthetic pathways of rice have been identified. The proposed experiments are currently ongoing.