Fundamental understanding of phenylpropanoid, lignin and flavonoid biosynthesis regulated by metabolon formation in grasses for precise manipulation to improve biomass utility

对草类代谢形成调节的苯丙素、木质素和类黄酮生物合成的基本了解，以进行精确操作以提高生物质利用率

• 批准号: 22K20590
• 负责人: Lam PuiYing
• 金额: $ 1.83万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-08-31 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22K20590/
• 关键词: lignin; flavonoids; phenylpropanoids; metabolon formation; grasses

The proposed research is aimed to understand the global organization of metabolons (protein-protein interaction networks) of phenylpropanoid, lignin and flavonoid biosynthetic enzymes that governs metabolite channelling and crosstalk between these pathways in grasses using rice as a model, and to elucidate how metabolon formation controls metabolic channeling in phenylpropanoid, lignin and flavonoid biosynthesis. Through in silico analysis, all the putative and known enzymes in the lignin, flavonoid and phenylpropanoid biosynthetic pathways of rice have been identified. The proposed experiments are currently ongoing.

本研究旨在以水稻为模型，了解苯丙素、木质素和类黄酮生物合成酶的代谢产物（蛋白质-蛋白质相互作用网络）的全局组织，控制这些途径之间的代谢物通道和串导，并阐明代谢形成如何控制苯丙素、木质素和类黄酮生物合成中的代谢通道。通过硅分析，确定了水稻木质素、类黄酮和苯丙素生物合成途径中所有已知和推测的酶。拟议的实验目前正在进行中。