Study of the neural mechanisms involved in the disability of future prediction in depression

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The purpose of this study was to reveal the neural mechanisms involved in the disability of future prediction in depression and the effects of cognitive behavioral therapy. Using the functional magnetic resonance imaging and delay discounting task, we compared depressed patients with healthy controls in the brain activity during delay discounting task. And, patients' brain activity during delay discounting task was compared before cognitive behavioral therapy and after that. As a result, we confirmed that depressed patients show the high delely discounting of loss comparting to healthy controls. We revealed that depressed patients' high delay discounting and neural activity related delay discounting was weakened by the cognitive behavioral therapy.