Methodology development for acquisition of a numerous number of new natural products from filamentous

在酵母细胞中成功构建了多个真菌次生代谢物的生物合成基因，并在酵母中通过异源生产成功获得了由它们生物合成的天然产物。我也为一些丝状真菌的生物合成研究开发了分子遗传学系统。我获得了一些天然产物，其中一些是新的/新颖的，通过破坏参与调节生物合成基因的基因。然后我发现几个次生代谢物参与了毛囊的转录和性发育（性孢子的形成）的调节。

A number of biosynthetic genes for fungal secondary metabolites were successfully reconstructed in yeast cells, and I successfully obtained natural products biosynthesized by them through heterologous production in yeast. I also developed molecular genetics systems for biosynthetic studies in some filamentous fungi. And I obtained a number of natural products, some of which are new/novel, through disruptions of genes involved in regulation of biosynthetic genes. I then found that several secondary metabolites are involved in regulation of transcription and sexual development (formation of sexual spores) in Chaetomium globosum.