Fabrication of novel apatite coating implant based on new concept

基于新理念的新型磷灰石涂层植入物的制作

• 批准号: 23890154
• 负责人: VALANEZHAD S.A
• 金额: $ 2.08万
• 依托单位: Chubu University (2012)Kyushu University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890154/
• 关键词: Ti インプラント; アパタイトコーティング; リン酸亜鉛; 生体適合性; 界面強度3-2.リン酸亜鉛から HAp への組成変換; Tiインプラント; 界面強度

Aim of this study is to fabricate hydroxyapatite(HAp) coating titanium(Ti) which shows high adhesivestrength between HAp coating and Ti substrate and chemically stable with time after implantation whencompared to HAp coating prepared by plasma spraying method. Zinc phosphate coating was successfullyprepared on Ti implant using our original method employing industrial zinc phosphate coating mixed withhydrothermal treatment. Subsequently the zinc phosphate could transform to HAp by treating withappropriate calcium salt solution. Adhesive strength between obtained coating and Ti substrate was 36.7 ±17 MPa which was approximately 4 times compared to that obtained by plasma spraying method. In vitroosteoconductivity evaluated using rat bone marrow cells indicated that cell attachment, proliferation,differentiation and calcification for HAp coating were significantly higher than that for non-treated Ti. Itis concluded that novel treatment proposed in this study would be useful for ostconductive treatment ofTi implant.

本研究的目的是制备羟基磷灰石（HAp）涂层钛（Ti），与等离子喷涂法制备的HAp涂层相比，羟基磷灰石（HAp）涂层与Ti基体之间具有较高的粘附强度，并且在注入后具有较长的化学稳定性。采用我们独创的方法，将工业磷酸锌涂层与水热处理混合，在钛植入体上成功制备了磷酸锌涂层。然后用适当的钙盐溶液处理磷酸锌，使其转化为HAp。所得涂层与Ti基体的结合强度为36.7±17 MPa，约为等离子喷涂法的4倍。利用大鼠骨髓细胞进行的体外骨电导率评价表明，羟基磷灰石涂层的细胞附着、增殖、分化和钙化明显高于未处理的钛涂层。因此，本研究提出的新型治疗方法对钛种植体的导通治疗有一定的指导意义。

项目成果

Hydroxyapatite Coating on ZincPhosphatized Titanium.

磷酸锌钛上的羟基磷灰石涂层。

• 发表时间: 2012
• 作者: Alireza Valanezhad;Kanji Tsuru;MichitoMaruta;Shigeki Matsuya;Kunio Ishikawa.
• 通讯作者: Kunio Ishikawa.

A new biocompatible coating layer applied on titanium substrates using a modified zinc phosphatizing method

• DOI: 10.1016/j.surfcoat.2011.09.064
• 发表时间: 2012-01
• 期刊: Surface & Coatings Technology
• 影响因子: 5.4
• 作者: A. Valanezhad;K. Tsuru;Michito Maruta;Giichiro Kawachi;S. Matsuya;K. Ishikawa

Protectivity and Adhesive Strength of Zinclipscombite Coating on 316L Stainless Steel.

316L 不锈钢上 Zinclipscombite 涂层的保护性和粘合强度。

• 发表时间: 2012
• 作者: Alireza Valanezhad;Kanji Tsuru;Michito Maruta;Shigeki Matsuya;Kunio Ishikawa.
• 通讯作者: Kunio Ishikawa.

A Novel HAp Coating Method on Titanium.

钛上新型 HAp 涂层方法。

• 发表时间: 2011
• 作者: Aireza Valanezhad;Kanji Tsuru;MichitoMaruta;Shigeki Matsuya;Kunio Ishikawa.
• 通讯作者: Kunio Ishikawa.

Hydroxyapatite Coating on Zinc Phosphatized Titanium

磷酸锌钛上的羟基磷灰石涂层

• 作者: Aireza Valanezhad;Kanji Tsuru;MichitoMaruta;Shigeki Matsuya;Kunio Ishikawa.;Furuhashi A et al;Alireza Valanezhad et al.
• 通讯作者: Alireza Valanezhad et al.