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DEVELOPMENT OF FUNCTIONAL BIOMATERIALS APPLIED APATITE-COATING SYSTEM

功能性生物材料应用磷灰石涂层体系的研制

基本信息

批准号：
06454563
负责人：
MORIWAKI Yutaka
金额：
$ 4.42万
依托单位：
ASAHI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

In this invesitigation, the apatite-metal composite biomaterials excellent for both strength and biocompatibility have been developed by coating the apatite on the metal surface using two step fusion method based on the build-up technique. Before everything, the ideal shapes of artificial tooth roots in clinical use were examined by carrying out the three dimensional finite element analysis for the shape design of apatite coating artficial tooth root. And from the study of fracture toughness, fracture mechanism and fatigue and life prediction of apatite ceramics, it was clarified that the lower value of toughness of apatiteceramics was serious problem in case of combining apatite with metal.The improvement in quality of apatite coating layr which has deteriorated in fusing by plasma has been performed using by laser light. Moreover, for expanding the application by more increase of both biocompatibility and toughness, the apatite collagen combination was attempted, and was comfirmed that the apatite would bonded chemically with collagen together, through the basic experiment made to deposit the apatite on the collagen fiber. The trial apatite-collagen complexes were tested by the experiment with animals, and was found to be usefull for an absorbable artficial bone filling material.On the other hand, the carbonate apatite was synthesized and sintered to develop the absobable apatite ceramics. By the investigation on sinterability and solubility in detail, the trial products similar to natural bone apatite were made, and was verified to be available for a bone filling material by bone formation experiment using animals.Furthermore, the early stage adhesiveness of osteoblast on apatite-coated titanium was examined by dipping into the artificial body fluid, it was confirmed that the ability of cell adhesion increased effectively by depositing the apatite crystal on the surface of titanium.

本研究采用基于堆焊技术的两步熔融法在金属表面包覆磷灰石，制备了具有良好强度和生物相容性的磷灰石-金属复合生物材料。首先对磷灰石涂层人工牙根的形状设计进行了三维有限元分析，以检验临床上理想的人工牙根形状。通过对磷灰石陶瓷断裂韧性、断裂机理、疲劳寿命预测的研究，阐明了磷灰石陶瓷韧性值偏低是磷灰石与金属结合时的严重问题，并采用激光对等离子熔凝后变质的磷灰石涂层进行了改性。此外，为了进一步提高材料的生物相容性和韧性，扩大其应用范围，尝试了磷灰石与胶原的复合，并通过在胶原纤维上存款磷灰石的基础实验，证实了磷灰石与胶原的化学结合。通过动物实验验证了所制备的磷灰石-胶原复合物是一种可吸收的人工骨填充材料。另一方面，合成了碳酸磷灰石，并进行了烧结，制备了可吸收的磷灰石陶瓷。通过对烧结性和溶解性的详细研究，制备了类似于天然骨磷灰石的试品，并通过动物成骨实验验证了其可作为骨填充材料，此外，还通过浸入人工体液的方法检测了成骨细胞在磷灰石涂层钛上的早期粘附，证实了通过在钛表面上沉积磷灰石晶体有效地提高了细胞粘附能力。