Studies on the biofunction of seaweed extract for osteoporosis prevention

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In this study, we found that Gelidium elegans Katzing methanol extract (GME) suppressed the osteoclast differentiation.To clarify this mechanism, we investigated the major and important gene expression in osteoclast differentiation. NFATc1 and JNK gene expression were decreased in osteoclast cultured with GME. It was revealed that GME was operated at the downstream of TRAF6. Moreover, the reduction of gene expression level of JNK and NFATc1 was induced by GME treatment.These results from were suggested that GME carried out suppression of osteoclast differentiation in the intracellular signal transduction via RANK.