Automatic Single Cell Analysis System inside ESEM

ESEM 内的自动单细胞分析系统

• 批准号: 24860032
• 负责人: SHEN Yajing
• 金额: $ 1.16万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24860032/
• 关键词: ナノロボット; 単一細胞解析; 自動制御

In this research, an automatic single cell analysissystem using micro/nano tools and nano robot inside an environmental scanning electron microscope (ESEM) is proposed.In this research, we propose the single cell analysis based on micro/nano tool and nano robotinside ESEM. Moreover, we will develop an automatic system for the single cell analysis. Therefore, any researchers can use this system easily, and a series of single cell analysis tasks can be performed accurately at nano scale. This system provides us a novel method to get accuracy information of single cell, which will help us to understand the cell mechanism better. It will benefit the biological and medical fields, such as single cell surgeryand new drug development.

在本研究中，提出了一种在环境扫描电子显微镜（ESEM）内使用微纳工具和纳米机器人的自动单细胞分析系统。在这项研究中，我们提出了基于微纳工具和纳米机器人的单细胞分析。此外，我们将开发一个单细胞分析的自动系统。因此，任何研究人员都可以轻松地使用该系统，并且可以在纳米尺度上精确地执行一系列单细胞分析任务。该系统为我们提供了一种获取单细胞精确信息的新方法，有助于我们更好地了解细胞的机理。它将有利于生物和医学领域，如单细胞手术和新药开发。

项目成果

"Nano-needle for Individual Cell Stiffness Determination at Various Humidity Conditions by Nano Manipulation"

“通过纳米操作在不同湿度条件下测定单个细胞硬度的纳米针”

• 期刊: Nanotechnology
• 影响因子: 3.5
• 作者: Yajing Shen;Masahiro Nakajima;Zhan Yang;Hirotaka Tajima;Zoran Najdovski;Michio Homma and Toshio Fukuda
• 通讯作者: Michio Homma and Toshio Fukuda

3D Cell Assembly based on Electro Deposition of Calcium Alginate

基于海藻酸钙电沉积的 3D 电池组装

• 发表时间: 2012
• 作者: Yajing Shen;Masahiro Nakajima;Chengzhi Hu;Tao Yue;Hirotaka Tajima and Toshio Fukuda
• 通讯作者: Hirotaka Tajima and Toshio Fukuda

Biodegradable porous sheet-like scaffolds for soft-tissue engineering using a combined particulate leaching of salt particles and magnetic sugar particles

• DOI: 10.1016/j.jbiosc.2013.01.011
• 发表时间: 2013-07-01
• 期刊: JOURNAL OF BIOSCIENCE AND BIOENGINEERING
• 影响因子: 2.8
• 作者: Hu, Chengzhi;Tercero, Carlos;Arai, Fumihito
• 通讯作者: Arai, Fumihito

Auto nanomanipulation system for single cell mechanical property characterization inside an environmental SEM

• DOI: 10.1109/iros.2012.6385731
• 发表时间: 2012-12
• 期刊: 2012 IEEE/RSJ International Conference on Intelligent Robots and Systems
• 作者: Yajing Shen;M. Nakajima;M. Homma;T. Fukuda

Nano needle with buffering beam for single cell stiffness measurement by nanorobotic manipulators inside ESEM

• DOI: 10.1109/nano.2012.6321995
• 发表时间: 2012-10
• 期刊: 2012 12th IEEE International Conference on Nanotechnology (IEEE-NANO)
• 作者: Yajing Shen;M. Nakajima;Zhan Yang;M. Homma;T. Fukuda