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Molecular mechanisms of the cellular coupling in the SCN during postnatal development

Molecular mechanisms of the cellular coupling in the SCN during postnatal development
出生后发育过程中 SCN 细胞耦合的分子机制
批准号:
24890001
负责人:
ONO Daisuke
金额:
$1.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-08-31 至 2014-03-31

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中文摘要
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英文摘要
We found that Cry1 and Cry2 are not essential for the circadian rhythm generation in the SCN cells, and are necessary for the development of intercellular networks in the adult SCN (Ono et al Nat. Commun. 2013). We also found that neonatal exposure to constant light compensates CRY functions for the disruption of circadian behavioral rhythms under constant dark (Ono et al PLOS ONE. 2013).In order to understand the role of VIP signaling in the CryDKO SCN during development, CryDKO mice were bred with VIP receptor (VPAC2) KO mice. We measured PER2::LUC bioluminescence in the SCN from CryDKO-VPAC2KO mice.
期刊论文(41)
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会议论文
Cellular oscillators in the suprachiasmatic nucleus for behavior rhythm expression in the mouse lacking CRYPTOCHROME. In : Honma K. ed
缺乏 CRYPTOCHROME 的小鼠视交叉上核中的细胞振荡器用于行为节律表达。
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [Honma S, Ono D and Honma K]
通讯作者: Ono D and Honma K
幼少期の光で,遺伝性概日リズム障害を克服
用幼儿期的光克服遗传性昼夜节律紊乱
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.1038/embor.2012.37
发表时间: 2012-05
期刊: EMBO reports
影响因子: 7.7
作者: [H. Yoshitane;S. Honma;Kiyomichi Imamura;H. Nakajima;Shin‐ya Nishide;Daisuke Ono;H. Kiyota;Naoya Shinozaki;Hirokazu Matsuki;Naoya Wada;H. Doi;T. Hamada;K. Honma;Y. Fukada]
通讯作者: H. Yoshitane;S. Honma;Kiyomichi Imamura;H. Nakajima;Shin‐ya Nishide;Daisuke Ono;H. Kiyota;Naoya Shinozaki;Hirokazu Matsuki;Naoya Wada;H. Doi;T. Hamada;K. Honma;Y. Fukada
Cry1/Cry2ダブルノックアウトマウス視交叉上核の概日リズムの生後発達
Cry1/Cry2双敲除小鼠视交叉上核的出生后昼夜节律发育
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [小野大輔, 本間さと, 本間研一]
通讯作者: 本間研一
27
    Development of planar doppler velocimetry system of shock-wave/boundary layer interaction
    • 批准号:
      24760141
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $1.83万
    • 财政年份:
      2012
    • 负责人:
      ONO Daisuke
    • 依托单位:
    The fabrication of biomimetic β-TCP showing bone remodelingactivity
    • 批准号:
      23792283
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $0.92万
    • 财政年份:
      2011
    • 负责人:
      ONO Daisuke
    • 依托单位:
    Synthesis and Properties of Novel Amphiphilic Compounds Bearing Decomposition Function
    海外基金