The elucidation of myocardial protection effect and the development of myocardial protective strategy by beta-blocker, landiolol, in children.

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In children with congenital heart disease patients who were scheduled for a cardiac surgery under cardio-pulmonary bypass, myocardial damage markers, cytokines, cardiac function, prognostic factors between the two groups of landiolol administration group and non-administration group, the myocardial protective effect of beta-blocker, landiolol, were compared.In landiolol administration group, increase of cytokines and myocardial damage marker were tended to be suppressed, cardiac function was also well maintained after surgery. In addition, post-operative hospital stay and intensive care unit admission period tended to be shortened in landiolol group.Administration of landiolol in the perioperative period possibly improves the prognosis for the patients with the congenital heart disease by the myocardial protective effect.