Efficacy of slow-rate repetitive transcranial magnetic stimulation in the treatment of depression.

慢速重复经颅磁刺激治疗抑郁症的疗效。

• 批准号: 17591231
• 负责人: MATSUMOTO Naoki
• 金额: $ 2.3万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591231/
• 关键词: depression; repetitive transcranial magnetic stimulation; cognitive function; 低頻度反復的経頭蓋磁気刺激

We investigated the antidepressant efficacy and its effect on neurocognitive function of repetitive transcranial magnetic stimulation (rTMS) in the treatment of refractory depression. Participants received rTMS applied to the left dorsolateral prefrontal cortex (10 Hz, 110% motor threshold, 20 trains of 5 seconds' duration with a 55-second intertrain interval, resulting in a total of 1000stimuli per session for 15 days). Half number of the participants showed a decrease of more than 50% in Hamilton Rating Scale for Depression score after rTMS treatment, and the effect lasted 2 months from the end of the study periods. No adverse effects were observed on cognitive performance measured by Wisconsin Card Sorting Test and Frontal Assessment Battery. Our results demonstrate that rTMS, conservatively spoken, might have beneficial antidepressant effects and had no deterioration of cognitive performance in a 3-week trial. Repetitive transcranial magnetic stimulation may be a useful adjunctive treatment for drug-resistant depressed patients.

目的探讨重复经颅磁刺激（rTMS）治疗难治性抑郁症的疗效及其对神经认知功能的影响。受试者接受了应用于左背外侧前额叶皮层的rTMS（10 Hz，110%运动阈值，20个持续时间为5 s的训练，训练间隔为55 s，每次训练共1000个刺激，持续15 d）。半数受试者经rTMS治疗后汉密尔顿抑郁量表评分下降50%以上，且效果持续2个月。未观察到对威斯康星州卡片分类测试和正面评估组合测量的认知表现的不良影响。我们的研究结果表明，保守地说，rTMS可能具有有益的抗抑郁作用，并且在3周的试验中没有认知能力的恶化。重复经颅磁刺激可能是治疗耐药抑郁症的有效方法。

项目成果

Donepezil in the treatment of musical hallucinations

• DOI: 10.1111/j.1440-1819.2007.01636.x
• 发表时间: 2007-04-01
• 期刊: PSYCHIATRY AND CLINICAL NEUROSCIENCES
• 影响因子: 11.9
• 作者: Ukai, Satoshi;Yamamoto, Masakiyo;Takeda, Masatoshi
• 通讯作者: Takeda, Masatoshi

Cognitive rehabilitation in schizophrenia.

精神分裂症的认知康复。

• 发表时间: 2006
• 期刊: Schizophrenia Frontier 7(4)
• 作者: Ozawa;H.;Naoki Katsumoto et al.
• 通讯作者: Naoki Katsumoto et al.

統合矯症患者の運動皮質の頭蓋磁気刺激による興奮性の検討

运用障碍患者运动皮层颅磁刺激兴奋性检查

• 发表时间: 2005
• 期刊: 臨床神経生理学 33巻5号
• 作者: Yamamoto M;Ukai S;Shinosaki K;Ishii R;Kawaguchi S;Ogawa A;Mizuno-Matsumoto Y;Fujita N;Yoshimine T;Takeda M.;小瀬 朝海
• 通讯作者: 小瀬 朝海

ECTとrTMSによるうつの治療

ECT 和 rTMS 治疗抑郁症

• 发表时间: 2006
• 期刊: 脳と精神の医学 17巻3号
• 作者: Yamamoto M;et al.;鵜飼 渉 他;Perry G et al.;小澤寛樹;篠崎 和弘
• 通讯作者: 篠崎 和弘

Electro and magnetic stimulation therapy in major depression.

重度抑郁症的电和磁刺激疗法。

• 发表时间: 2005
• 期刊: Sogo rinsho 54(12)
• 作者: Suzuki K.;et al.;小瀬 朝海;正山 勝;篠崎 和弘;Yuji Kitabata et al.;Kazuhiro Shinosaki et al.
• 通讯作者: Kazuhiro Shinosaki et al.