Foundations of a good egg: correctly transitioning from mitosis to meiosis

好卵子的基础：从有丝分裂到减数分裂的正确过渡

• 批准号: DP240102956
• 负责人: A/Prof Josephine Bowles
• 金额: $ 56.07万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-25 至 2027-01-24
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102956
• 关键词: Foundations; good; egg; correctly; transitioning

Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initiate meiotic division instead. It is important to understand all the fundamental processes that occur during normal germ cell development so that, in the future, we can use this knowledge to support agricultural advances, rescue endangered species and solve human problems such as infertility and genetic disease.

生产可行的后代对于任何物种的生存至关重要。在所有性繁殖物种中，这都需要独特的细胞类型，即生殖细胞。生殖细胞经历一种特殊的细胞分裂，称为减数分裂，因此它们最终可以产生配子（雄性的精子和女性的卵子）。该项目旨在发现生殖细胞如何停止细胞分裂的标准形式，称为有丝分裂，并启动减数分裂分裂。重要的是要了解正常生殖细胞发育过程中发生的所有基本过程，以便将来我们可以利用这些知识来支持农业进步，营救濒临灭绝的物种并解决人类问题，例如不孕症和遗传疾病。