Investigating spermatogonial stem cell allocation in the fetal testis

研究胎儿睾丸中精原干细胞的分配

• 批准号: DP180103811
• 负责人: A/Prof Josephine Bowles
• 金额: $ 24.47万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103811
• 关键词: Investigating; spermatogonial; stem; cell; allocation

This project aims to determine when and how spermatogonial stem cells (SSCs) are specified, and whether a genetic pathway that is used by in vitro stem cells is also employed, in vivo, by testicular stem cells. The project aims to deliver insight into the mechanisms of adult stem cell specification and regulation, in general. Intended practical outcomes of this work will underpin new methods for fertility management in animals (in agriculture and conservation of endangered species) and humans. Knowledge gained will inform our understanding of stem cell biology more broadly and guide efforts to treat infertility or control fertility in animals and humans.

该项目旨在确定精原干细胞（ssc）何时以及如何被指定，以及体外干细胞使用的遗传途径是否也被体内睾丸干细胞使用。该项目旨在深入了解成体干细胞的规范和调控机制。这项工作的预期实际成果将为动物（农业和濒危物种保护）和人类生育管理的新方法奠定基础。所获得的知识将使我们更广泛地了解干细胞生物学，并指导动物和人类治疗不孕症或控制生育能力的努力。