Investigating spermatogonial stem cell allocation in the fetal testis

研究胎儿睾丸中精原干细胞的分配

• 批准号: DP180103811
• 负责人: A/Prof Josephine Bowles
• 金额: $ 24.47万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103811
• 关键词: Investigating; spermatogonial; stem; cell; allocation

This project aims to determine when and how spermatogonial stem cells (SSCs) are specified, and whether a genetic pathway that is used by in vitro stem cells is also employed, in vivo, by testicular stem cells. The project aims to deliver insight into the mechanisms of adult stem cell specification and regulation, in general. Intended practical outcomes of this work will underpin new methods for fertility management in animals (in agriculture and conservation of endangered species) and humans. Knowledge gained will inform our understanding of stem cell biology more broadly and guide efforts to treat infertility or control fertility in animals and humans.

该项目旨在确定何时以及如何指定精子干细胞（SSC），以及是否还通过睾丸干细胞在体内使用了体外干细胞使用的遗传途径。该项目旨在深入了解成年干细胞规范和调节的机制。这项工作的预期实际结果将为动物（农业和保护濒危物种的农业）和人类的生育能力管理的新方法。获得的知识将为我们对干细胞生物学的理解提供更多信息，并指导治疗动物和人类生育能力的努力。