How do mammalian germ cells transition from mitosis to meiosis?

哺乳动物生殖细胞如何从有丝分裂转变为减数分裂？

• 批准号: DP200102896
• 负责人: A/Prof Josephine Bowles
• 金额: $ 35.46万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102896
• 关键词: How; do; mammalian; germ; cells

This project aims to determine how germ cells are regulated in the mammalian embryo. Germ cells go on to form the sperm and eggs and are, therefore, critical for reproduction. In particular, this project expects to generate new knowledge about the process of meiosis, a cellular process that is specific to the germ cells. Expected outcomes will inform efforts to control fertility and infertility in livestock, humans and other mammalian animals (e.g. pets and endangered species). They are also likely to inform the discipline of stem cell biology in general.

该项目旨在确定生殖细胞在哺乳动物胚胎中是如何调节的。生殖细胞继续形成精子和卵子，因此对生殖至关重要。特别是，该项目预计将产生有关减数分裂过程的新知识，减数分裂是生殖细胞特有的细胞过程。预期成果将为控制牲畜、人类和其他哺乳动物（如宠物和濒危物种）的生育和不育提供信息。它们也可能为干细胞生物学学科提供一般信息。