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Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans

Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
1-溴丙烷对人体中枢神经系统和造血功能的毒性研究
批准号:
21406017
负责人:
ICHIHARA Gaku
金额:
$11.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
The analysis of workers exposed to 1-bromopropane and non-exposed workers was conducted using ANOVA followed by Dunnett's multiple comparison and regression analysis. The result showed dose-dependent increase in distal latency, threshold for vibration sense, LDH, TSH, FSH and dose-dependent decrease in sensory nerve conduction velocity, red blood cell, hematocrit. The cases intoxicated with 1-bromopropane showed degeneration of peripheral nerve histopathologically and the abnormality in the central nervous system.
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会议论文
Comparative study on susceptibility to 1-bromopropane in three mice strains.
三种品系小鼠对1-溴丙烷敏感性的比较研究。
DOI: --
发表时间: 2009
期刊: Toxicol Sci 112(1)
影响因子: --
作者: [Liu F, Ichiharhar S, Mohideen SS, Sai U, Kitoh J, Ichihara G.]
通讯作者: Ichihara G.
Central nerve system toxicity of 1-bromopropane: an oxidative stress hypothesis.
1-溴丙烷的中枢神经系统毒性:氧化应激假说。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [原田久美, 小川智子, 角大悟, 姫野誠一郎., Subramanian K.]
通讯作者: Subramanian K.
DOI: 10.1097/jom.0b013e3181eaded7
发表时间: 2010-07
期刊: Journal of Occupational and Environmental Medicine
影响因子: 3.2
作者: [Wei-hua Li;E. Shibata;Zhijun Zhou;S. Ichihara;Hailan Wang;Qiang-yi Wang;Jiefei Li;Lingyi Zhang;K. Wakai;Y. Takeuchi;Xun-cheng Ding;G. Ichihara]
通讯作者: Wei-hua Li;E. Shibata;Zhijun Zhou;S. Ichihara;Hailan Wang;Qiang-yi Wang;Jiefei Li;Lingyi Zhang;K. Wakai;Y. Takeuchi;Xun-cheng Ding;G. Ichihara
プロテオミクス技術を用いた1-ブロモプロパンによる中枢神経障害に関連するタンパク質の探索日本ヒトプロテオーム機構
利用蛋白质组学技术寻找与 1-溴丙烷引起的中枢神经系统损伤相关的蛋白质 Japan Human Proteome Organization
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [安藤知沙, 市原佐保子, 葛谷憲太郎, 常杰, 黄振烈, 市原学, 及川伸二]
通讯作者: 及川伸二
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    • 批准号:
      23659326
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
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    • 批准号:
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    • 项目类别:
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    • 资助金额:
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