Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
Investigation on toxicity of 1-bromopropane to central nervous system and hematopoetic function in humans
批准号:
21406017
负责人:
ICHIHARA Gaku
金额:
$11.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The analysis of workers exposed to 1-bromopropane and non-exposed workers was conducted using ANOVA followed by Dunnett's multiple comparison and regression analysis. The result showed dose-dependent increase in distal latency, threshold for vibration sense, LDH, TSH, FSH and dose-dependent decrease in sensory nerve conduction velocity, red blood cell, hematocrit. The cases intoxicated with 1-bromopropane showed degeneration of peripheral nerve histopathologically and the abnormality in the central nervous system.
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Comparative study on susceptibility to 1-bromopropane in three mice strains.
三种品系小鼠对1-溴丙烷敏感性的比较研究。
DOI:
--
发表时间:
2009
期刊:
Toxicol Sci 112(1)
影响因子:
--
作者:
[Liu F, Ichiharhar S, Mohideen SS, Sai U, Kitoh J, Ichihara G.]
通讯作者:
Ichihara G.
Central nerve system toxicity of 1-bromopropane: an oxidative stress hypothesis.
1-溴丙烷的中枢神经系统毒性:氧化应激假说。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[原田久美, 小川智子, 角大悟, 姫野誠一郎., Subramanian K.]
通讯作者:
Subramanian K.
DOI:
10.1097/jom.0b013e3181eaded7
发表时间:
2010-07
期刊:
Journal of Occupational and Environmental Medicine
影响因子:
3.2
作者:
[Wei-hua Li;E. Shibata;Zhijun Zhou;S. Ichihara;Hailan Wang;Qiang-yi Wang;Jiefei Li;Lingyi Zhang;K. Wakai;Y. Takeuchi;Xun-cheng Ding;G. Ichihara]
通讯作者:
Wei-hua Li;E. Shibata;Zhijun Zhou;S. Ichihara;Hailan Wang;Qiang-yi Wang;Jiefei Li;Lingyi Zhang;K. Wakai;Y. Takeuchi;Xun-cheng Ding;G. Ichihara
プロテオミクス技術を用いた1-ブロモプロパンによる中枢神経障害に関連するタンパク質の探索日本ヒトプロテオーム機構
利用蛋白质组学技术寻找与 1-溴丙烷引起的中枢神经系统损伤相关的蛋白质 Japan Human Proteome Organization
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[安藤知沙, 市原佐保子, 葛谷憲太郎, 常杰, 黄振烈, 市原学, 及川伸二]
通讯作者:
及川伸二
Hyperphophatemia and hypozincemia affect peripheral nervous system in SHR/NDMCR-CP, a model of metabolic syndrome. Society of Toxicology
高磷血症和低锌血症影响代谢综合征模型 SHR/NDMCR-CP 中的周围神经系统。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Suzuki Y, et al]
通讯作者:
et al
共 87 条
Investigation on neurodegenerative effect of 1-bromopropane using new biomarkers
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批准号:24406018
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2012
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负责人:ICHIHARA Gaku
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依托单位:
Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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财政年份:2011
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负责人:ICHIHARA Gaku
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依托单位:
Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons
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批准号:22390120
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.56万
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财政年份:2010
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负责人:ICHIHARA Gaku
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依托单位:
Analysis of molecular and cellular targets in neurotoxicity of alternatives to ozone-depleting substances and establishment of biomarkers for the central nervous toxicity
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批准号:19390160
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资助金额:$12.15万
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财政年份:2007
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负责人:ICHIHARA Gaku
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依托单位:
Study on dose-dependency of the central nervous system toxicity of 1-bromopropane in humans
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批准号:17406017
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.77万
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财政年份:2005
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负责人:ICHIHARA Gaku
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依托单位:
Investigation on protein adduct produced by alternatives to ozone-depleting substances and susceptibility genes and establishment of new method for risk assessment.
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批准号:16390169
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.6万
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财政年份:2004
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负责人:ICHIHARA Gaku
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依托单位:
Investigation on neurologic abnormality induced by 1-bromoproane and individual variation in susceptibility
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批准号:14406015
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.28万
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财政年份:2002
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负责人:ICHIHARA Gaku
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依托单位:
INVESTIGATION ON TOXICITIES OF ALTERNATIVES FOR CHLOROFLUOROCARBONS AND ITS RISK ASSESSMENT USING MOLECULAR AND BIOLOGICAL MARKERS.
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批准号:13470088
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.28万
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财政年份:2001
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负责人:ICHIHARA Gaku
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依托单位:
Development Deregulating system for inhalation exposure to volatile organic chemicals (VOCs) for toxicity testing
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批准号:12557039
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负责人:ICHIHARA Gaku
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依托单位:
Study on mechanism of reproductive toxicity and neurotoxicity of 1-bromopropane, a new alternative to chlorofluorocarbons
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批准号:11670367
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:ICHIHARA Gaku
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依托单位:
海外基金