权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Construction and Control of Helical Supramolecules Based on Sequential Information of Carbon-Chains

基于碳链序列信息的螺旋超分子的构建与控制

基本信息

批准号：
10450353
负责人：
MIYATA Mikiji
金额：
$ 8.32万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

We have been studying on inclusion compounds of steroids over ten years. In this research project we aim to construct and control helical supramolecules in inclusion crystals on the basis of sequential information of chiral carbon-chains. Such a study may enable us to establish the concept of molecular information and expression of chiral carbon-chain compounds, such as steroids. The results are summarized as follows ;1. We synthesized many steroidal derivatives involving sequential information, starting from commercially availabe cholic and deoxycholic acids. Such compounds were found to form inclusion crystals composed of helical assemblies in most of the cases.2. The inclusion behaviors of the steroidal hosts were checked by using more than one hundred guests. We determined a scope of the guest components included. The scope for each host varied from one case to another. We accumulated inclusion data necessary for considering possible mechanism of the host-guest complexation from a viewpoint in size, shape, chirality and polarity.3. We analyzed the resulting inclusion compounds by means of powder and single crystal X-ray crystallography, leading to the finding of over fifty helical structures of the inclusion compounds. We analyzed the helical assemblies from various aspects of the helical structures by using various softwares. For example, molecular graphics study helped us to evaluate a relation between the original molecular structures and the resulting helical structures.4. We confirmed that multiple combinations among the hydrogen-bonding groups may play an important role in determining the helical structures. Now we believe that chiral carbon-chain compounds tend to construct comprehensive helical assemblies on the basis of diversible hydrogen bonds and van der Waals interaction due to facially amphiphilicity.

我们对甾体类化合物的包合物进行了十多年的研究。本研究旨在利用手性碳链的序列信息构建和控制包合晶体中的螺旋超分子。这一研究有助于我们建立手性碳链化合物（如甾体化合物）的分子信息概念和表达。研究结果如下：1.我们从市售的胆酸和脱氧胆酸出发，合成了许多涉及序列信息的甾体衍生物。发现这些化合物在大多数情况下形成由螺旋组装体组成的包合晶体.用100多个客体考察了甾体主体的包合行为。我们确定了包括的客户组件的范围。每种宿主的范围因情况而异。从包合物的大小、形状、手性和极性等方面为研究主客体络合的可能机理积累了必要的数据.我们通过粉末和单晶X-射线晶体学分析了所得包合物，导致发现超过50个螺旋结构的包合物。利用各种软件从螺旋结构的各个方面对螺旋装配体进行了分析。例如，分子图形学的研究帮助我们评估了原始分子结构和螺旋结构之间的关系.我们证实了氢键基团之间的多重组合可能在决定螺旋结构中起重要作用。目前我们认为手性碳链化合物由于表面的两亲性，在可分散的氢键和货车德瓦耳斯相互作用的基础上，往往会形成复杂的螺旋组装体。