课题基金 / 基金详情

ANALYSIS OF CHARACTERISTICS AND PATHOGENESIS OF SKIN INJURY INDUCED BY ENVIRONMENTAL CHEMICALS AND ULTRAVIOLET LIGHT

ANALYSIS OF CHARACTERISTICS AND PATHOGENESIS OF SKIN INJURY INDUCED BY ENVIRONMENTAL CHEMICALS AND ULTRAVIOLET LIGHT
环境化学物质和紫外线所致皮肤损伤的特点及发病机制分析
批准号：
10460139
负责人：
DOI Kunio
金额：
$7.23万
依托单位：
THE UNIVERSITY OF TOKYO
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
项目状态：
已结题
起止时间：
1998 至 2000
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10460139/
关键词：
Environmental chemicalsUltraviolet lightSkin injuryApoptosisHairless dogsHairless ratsWBNILA-Ht ratT-2 toxinbasal cell apoptosisIQIJic mousepicryl chloridecontact dermatitisUV irradiationHaieless dogSkin res

项目摘要

项目成果

DOI Kunio的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Skin reaction to ultraviolet light irradiation was examined using hairless dogs and rats. Erythema, sunburn and suntan reactions were observed as in humans. Histopathological examination for the skin revealed apoptotic cell death in the epidermal lesions. Involvement of p53 and p21 genes in the induction of apoptosis was suggested. Skin lesions were also induced by the application of an agricultural chemical, Maneb. The lesions were enhanced by ultraviolet irradiation in dogs, but not in rats. There may be a species differences in the skin reaction.Skin reaction to topical application of formaldehyde and hydrogen peroxide was clarified using hairless rats. Skin application of a mycotoxin, T-2 toxin, was additionally performed. The results indicated apoptotic cell death of epidermal cells and endothelial injury in the dermis.The results of the research clarified characteristics and pathogenesis of the skin injury induced by environmental chemicals and ultraviolet light.
期刊论文(106)
专著(0)
科研奖励(0)
会议论文
Ikeda M., Kuroki K., Suzuki H., Nakayama H., Saegusa J.and Doi K.: "Picryl chloride-induced allergic dermatitis in IQI/Jic female mice."Exp.Toxicol.Pathol.. 52. 235-240 (2000)
Ikeda M.、Kuroki K.、Suzuki H.、Nakayama H.、Saegusa J. 和 Doi K.：“三氯丙烯在 IQI/Jic 雌性小鼠中诱发过敏性皮炎。”Exp.Toxicol.Pathol.. 52. 235-
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Iwamoto S.,Nakayama H.,Dot K.: "Morphological and morphometrical study on the dorsal skin of Wistar and WBN/ILA-Ht rats in their developing stage.Evaluation of the proliferation and ......."Histology and Histopathology. 13. 981-988 (1998)
Iwamoto S.、Nakayama H.、Dot K.：“Wistar 和 WBN/ILA-Ht 大鼠发育阶段背部皮肤的形态学和形态测量研究。增殖评估和……”组织学和
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Albarenque S.M. et al.: "Kinetics and distribution of transforming growth factor (TGF)-β1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical applicayion of T-2 toxin"Exp Toxicol Pathol. 52. 29-301 (2000)
Albarenque S.M. 等人：“局部应用 T-2 毒素后，少毛 WBN/ILA-Ht 大鼠背部皮肤中转化生长因子 (TGF)-β1 mRNA 的动力学和分布”Exp Toxicol Pathol。 (2000)
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Kimura T.and Doi K.: "Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids."Toxicologic Pathology. 27. 528-535 (1999)
Kimura T. 和 Doi K.：“无毛狗对皮质类固醇局部治疗的背部皮肤反应。”毒理学病理学。
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
共 51 条
    Mechanisms of chemical-induced fetal brain toxicity
    • 批准号：
      13460139
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $9.6万
    • 财政年份：
      2001
    • 负责人：
      DOI Kunio
    • 依托单位：
      The University of Tokyo
    USEFULNESS OF LABORATORY HAIRLESS DOGS IN THE FIELD OF DERMATOSURGERY
    • 批准号：
      11556059
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $8.51万
    • 财政年份：
      1999
    • 负责人：
      DOI Kunio
    • 依托单位：
      THE UNIVERSITY OF TOKYO
    USEFULNES OF LABORATORY HAIRLESS DOG IN THE DEVELOPMENT OF DERMAL MEDICINES AND COSMETICS
    • 批准号：
      08556049
    • 项目类别：
      Grant-in-Aid for Scientific Research (A)
    • 资助金额：
      $6.34万
    • 财政年份：
      1996
    • 负责人：
      DOI Kunio
    • 依托单位：
      The University of Tokyo
    MECHANISM OF GALACTOSAMINE-INDUCED HEPATOCYTE APOPTOSIS
    • 批准号：
      07456139
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $4.22万
    • 财政年份：
      1995
    • 负责人：
      DOI Kunio
    • 依托单位：
      The University of Tokyo
    海外基金