USEFULNES OF LABORATORY HAIRLESS DOG IN THE DEVELOPMENT OF DERMAL MEDICINES AND COSMETICS

实验室无毛狗在皮肤药物和化妆品开发中的用途

• 批准号: 08556049
• 负责人: DOI Kunio
• 金额: $ 6.34万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08556049/
• 关键词: Laboratory hailess dog; Sunscreens; Screening system; Hair growth stimulator; Anti-acne agent; Depigmenthing agent; Depressant of skin aging; 育毛剤; 薬効評価素; 発毛促進薬; 紫外線; 皮膚反応; サンスクリーン剤

Usefulness of laboratory hairless dog (LHD) which have been developed by us in the development of dermal medicines and cosmetics were investigated from the various viewpoints. The results of this study are summarized as follows.1) The epidermis of LHD contained abundant melanocytes. Their skin clearly showed UV-induced changes such as senburn and suntan reactions.2) Sunscreens effectively protected the skin of LHD from sunburn and suntan reactions induced by solar exposure or artificial UV-irradiation.3) Neonatal LHD developed hair growth reactions following minoxidil treatment.4) The spotted pigmentation occurring on the skin of adult LHD was depigmented by application of HQ.5) LHD developed spontaneous comedons in the skin and the severity of these lesions subsided with the application of anti-acne agents.6) Aging of the skin of LHD was delayed by all-trans-retinoic acid treatment.These results strongly suggest that LHD is very useful laboratory animal in the development of dermal medicines and cosmetics.

本文从多个角度探讨了实验室无毛犬（LHD）在皮肤药物和化妆品开发中的可行性。本研究的结果如下：1）LHD表皮含有丰富的黑素细胞。防晒霜能有效地保护LHD的皮肤免受日光暴露或人工紫外线照射引起的晒伤和晒黑反应; 3）新生儿LHD在米诺地尔治疗后出现毛发生长反应; 4）成人LHD皮肤上出现的斑点状色素沉着通过应用HQ而脱色。6）全反式维甲酸能延缓LHD的皮肤衰老，提示LHD是一种非常有用的皮肤药物和化妆品的实验动物。

项目成果

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Kimura T.：“Ohshima S.和 Doi K.墨西哥无毛狗的无毛和有毛后代的血液学和血清生化值。”

Kimura T.and Doi K.: "Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs." Hist.Histopathol.13. 29-36 (1998)

Kimura T. 和 Doi K.：“吲哚美辛对墨西哥无毛狗的无毛后代晒伤和晒黑反应的影响。”

Kimura T.and Doi K.: "Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendonts of Mexican hairless dogs." Lab.Anim.Sci.48. 469-475 (1998)

Kimura T. 和 Doi K.：“氢醌治疗墨西哥无毛犬无毛后代皮肤色素沉着的功效。”

Kimura T.and Doi K.: "Age-related changes in skin color and histologic features of hairless descendants of Mexican hairless dogs." Am.J.Vet.Sci.55. 480-486 (1994)

Kimura T. 和 Doi K.：“墨西哥无毛狗的无毛后代的皮肤颜色和组织学特征与年龄相关的变化。”

Ishii Y., Kimura T., Itagaki S.and Doi K.: "Ultrastructure of the dorsal skins of hairless descendants derived from Mexicam hairless dogs." Exp.Anim.44. 353-357 (1995)

Ishii Y.、Kimura T.、Itagaki S. 和 Doi K.：“Mexicam 无毛犬无毛后代背部皮肤的超微结构。”