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USEFULNES OF LABORATORY HAIRLESS DOG IN THE DEVELOPMENT OF DERMAL MEDICINES AND COSMETICS

USEFULNES OF LABORATORY HAIRLESS DOG IN THE DEVELOPMENT OF DERMAL MEDICINES AND COSMETICS
实验室无毛狗在皮肤药物和化妆品开发中的用途
批准号:
08556049
负责人:
DOI Kunio
金额:
$6.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
1996
资助国家:
日本
项目状态:
已结题
起止时间:
1996 至 1998

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中文摘要
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英文摘要
Usefulness of laboratory hairless dog (LHD) which have been developed by us in the development of dermal medicines and cosmetics were investigated from the various viewpoints. The results of this study are summarized as follows.1) The epidermis of LHD contained abundant melanocytes. Their skin clearly showed UV-induced changes such as senburn and suntan reactions.2) Sunscreens effectively protected the skin of LHD from sunburn and suntan reactions induced by solar exposure or artificial UV-irradiation.3) Neonatal LHD developed hair growth reactions following minoxidil treatment.4) The spotted pigmentation occurring on the skin of adult LHD was depigmented by application of HQ.5) LHD developed spontaneous comedons in the skin and the severity of these lesions subsided with the application of anti-acne agents.6) Aging of the skin of LHD was delayed by all-trans-retinoic acid treatment.These results strongly suggest that LHD is very useful laboratory animal in the development of dermal medicines and cosmetics.
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Kimura T.: "Ohshima S.and Doi K.Haematological and serum biochemicl values in hairless and haired descendants of Mexican hairless dogs." Lab.Anim.26. 214-218 (1992)
Kimura T.:“Ohshima S.和 Doi K.墨西哥无毛狗的无毛和有毛后代的血液学和血清生化值。”
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Kimura T.and Doi K.: "Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs." Hist.Histopathol.13. 29-36 (1998)
Kimura T. 和 Doi K.:“吲哚美辛对墨西哥无毛狗的无毛后代晒伤和晒黑反应的影响。”
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Kimura T.and Doi K.: "Age-related changes in skin color and histologic features of hairless descendants of Mexican hairless dogs." Am.J.Vet.Sci.55. 480-486 (1994)
Kimura T. 和 Doi K.:“墨西哥无毛狗的无毛后代的皮肤颜色和组织学特征与年龄相关的变化。”
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31
    Mechanisms of chemical-induced fetal brain toxicity
    • 批准号:
      13460139
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.6万
    • 财政年份:
      2001
    • 负责人:
      DOI Kunio
    • 依托单位:
    USEFULNESS OF LABORATORY HAIRLESS DOGS IN THE FIELD OF DERMATOSURGERY
    • 批准号:
      11556059
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.51万
    • 财政年份:
      1999
    • 负责人:
      DOI Kunio
    • 依托单位:
    ANALYSIS OF CHARACTERISTICS AND PATHOGENESIS OF SKIN INJURY INDUCED BY ENVIRONMENTAL CHEMICALS AND ULTRAVIOLET LIGHT
    • 批准号:
      10460139
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $7.23万
    • 财政年份:
      1998
    • 负责人:
      DOI Kunio
    • 依托单位:
    MECHANISM OF GALACTOSAMINE-INDUCED HEPATOCYTE APOPTOSIS
    • 批准号:
      07456139
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $4.22万
    • 财政年份:
      1995
    • 负责人:
      DOI Kunio
    • 依托单位:
    海外基金