USEFULNESS OF LABORATORY HAIRLESS DOGS IN THE FIELD OF DERMATOSURGERY

实验室无毛犬在皮肤外科领域的用途

• 批准号: 11556059
• 负责人: DOI Kunio
• 金额: $ 8.51万
• 依托单位: THE UNIVERSITY OF TOKYO
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11556059/
• 关键词: Laboratory hairless dogs; Dermatosurgery; Burn wound; Wound dressing; Q-switched ruby laser; Depigmentation; Rejuvenation; 実験用ヘアレス犬; 背部皮膚; 創傷被覆材; 絹フィブロイン; spotty pigmentation; Q-switched ruby laser; 創傷被覆材の評価系; キチン製材; キトサン製材; hairless dog /

Usefulness of laboratory hairless dogs (LHDs) in the field of dermatosurgery was investigated. As a result, it was clarified that LHDs were useful as a burn wound or skin injury healing model and efficacy and safety of several kinds of wound dressings were examined using these models. In addition, it was shown that LHDs were useful for the evaluation of efficacies of Q-switched ruby laser irradiation and hydroquinone on senile spotty pigmentation. Moreover depigmentation and rejuvenation effects of all-trans-retioic acid and kinetin on senile dorsal skin of LHDs were investigated, suggesting a usefulness of LHDs in those experiments.Thus the usefulness of LHDs in the field of dermatosurgery was clarified.

对实验室无毛犬（LHD）在皮肤外科领域的适应性进行了研究。因此，阐明了LHD可用作烧伤伤口或皮肤损伤愈合模型，并使用这些模型检查了几种伤口敷料的有效性和安全性。此外，LHD可用于评价Q开关红宝石激光照射和氢醌治疗老年斑色素沉着的疗效。此外，还研究了全反式维甲酸和激动素对老年性LHD患者背部皮肤的脱色和年轻化作用，表明LHD在这些实验中是有用的，从而阐明了LHD在皮肤外科领域的用途。

项目成果

Kimura T. and Doi K.: "Effects of indomethacin on sunbum and suntan reactions in harless descendants of Mexican Hairless dogs"Histol. Histopathol. 13. 29-36 (1998)

Kimura T. 和 Doi K.：“吲哚美辛对墨西哥无毛狗无毛后代晒伤和晒黑反应的影响”Histol。

Kimura T., Doi K.: "Dermatotoxicity due to wound dressing with chitosan and chitin in hairless dogs"Vet. Dermatol.. (in press). (2000)

Kimura T.，Doi K.：“无毛犬中使用壳聚糖和甲壳素进行伤口敷料导致的皮肤毒性”兽医。

Kimura T., Doi K.: "Dermatotoxicity due to wound dressings with chitosan and chitin in hairless dogs"Vet. Dermatol.. (in press). (2002)

Kimura T.，Doi K.：“无毛犬中含有壳聚糖和甲壳素的伤口敷料引起的皮肤毒性”兽医。

Kimura T., Doi K.: "Effects of all trans-retinoic acid on the dorsal skin of hairless dogs"Toxicol. Pathol.. Vol.26. 442-447 (1998)

Kimura T.，Doi K.：“所有反式视黄酸对无毛犬背部皮肤的影响”Toxicol。

Kimura T. and Doi K.: "Dorsai skin reactions of hairless dogs to topical treatment with corticosteroids"Tox. Path.. 27. 528-535 (1999)

Kimura T. 和 Doi K.：“无毛狗对皮质类固醇局部治疗的 Dorsai 皮肤反应”Tox。