Effect of concomitant exposure of endocrine disrupting chemicals and its risk assessment

内分泌干​​扰物同时暴露的影响及其风险评估

• 批准号: 10470096
• 负责人: MAKITA Yuji
• 金额: $ 5.06万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470096/
• 关键词: Edocrine disrupter; P,p'-DDE; Tributyltin(TBT); Combined effect; Wistar rat; アンドローゲン作用; 抗アンドローゲン作用; 哺乳動物; p,p'-DDE; P,P'-DDE; アンドーゲン作用; 生体影響; 複合汚染; 海産資源

P,p'-DDE(DDE) and tributyltin (TBT)have been ubiquitous in the environment and are suspected to be potent endocrine disrupters. DDE and TBT are considerably taken in Japan from marine products, in which they are included through bio-concentration and food chain. Above all, fetuses and neonates are highly susceptible to endocrine disrupters and faced with concurrent exposure of DDE and TBT through the maternal environment, where these substances are much contained in increased marine product intake during pregnancy and in milk during nursing period. Therefore, the combined effects of DDE and TBT on rat offspring were investigated by simultaneous administration of DDE and/or TBT in pregnant Wistar rats. In this study, TBT did suppress the growth and reduce the prostate weight of rat offspring, whereas DDE itself scarcely affected but restored the growth suppression and prostate weight reduction by TBT. These results indicate that TBT could affect the endocrine system of rat male offspring as well as that of marine prosobranch snails and suggest that TBT may exert its actions through the androgen receptor as DDE is known to be an androgen receptor antagonist in rats.

P，p‘-DDE(DDE)和三丁基锡(TBT)广泛存在于环境中，被认为是强有力的内分泌干扰物。在日本，DDE和TBT相当大程度上是从海产品中提取的，它们通过生物浓缩和食物链被包括在海产品中。最重要的是，胎儿和新生儿非常容易受到内分泌干扰物的影响，并面临着通过母体环境同时暴露于DDE和TBT的情况，这些物质在怀孕期间增加的海产品摄入量和哺乳期间的牛奶中含有很大一部分。因此，通过妊娠Wistar大鼠同时给予DDE和/或TBT来研究DDE和TBT对子代的联合作用。在本研究中，TBT确实抑制了大鼠子代的生长并减轻了其前列腺重量，而DDE本身几乎不影响而是恢复了TBT所致的生长抑制和前列腺重量减轻。这些结果表明，TBT可影响雄性子代和海洋螺类的内分泌系统，提示TBT可能是通过雄激素受体发挥作用的，因为DDE是一种雄激素受体拮抗剂。

项目成果

尾方里香 他: "トリブチルスズの妊娠期/授乳期曝露による母仔ラットへの影響"日本衛生学会雑誌. 54・1. 255 (1999)

Rika Ogata 等人：“妊娠/哺乳期间接触三丁基锡对母鼠和大鼠的影响”日本健康科学学会杂志 54, 1. 255 (1999)。

槙田裕之 他: "p,p'-DDEとトリブチルスズの複合投与による影響"日本衛生学会雑誌. 56・1(印刷中). (2001)

Hiroyuki Makita 等：“p,p-DDE 和三丁基锡联合给药的效果”，日本卫生学会杂志，56, 1（出版中）。

大村実, 増田義雄, 平田美由紀, 田中昭代, 尾方里香, 槇田裕之, 井上尚英: "六塩化ナフタレンの雄ラットへの胎児期暴露実験"日本衛生学会誌. 54.1. 245-246 (1999)

Minoru Omura、Yoshio Masuda、Miyuki Hirata、Akiyo Tanaka、Rika Ogata、Hiroyuki Makita、Naohide Inoue：“雄性大鼠六氯化萘的产前暴露实验”日本健康科学学会杂志 545-246（1999）。

Romero Y.: "Effects of p, p'-DDE on male reproductive organs in peripubertal Wistar rats following a single peritoneal injection"Fukuoka Acta Medica. 89.1. 64-72 (1998)

Romero Y.：“单次腹膜注射后 p, p-DDE 对青春期前 Wistar 大鼠雄性生殖器官的影响”福冈医学学报。

Makita Y, Tanaka A, Hirata M, Omura M, Ogata R: "Combined effects of p, p'-DDE and tributyltin on Wistar rat offspring"Fukuoka Acta Medica. (In press).

Makita Y、Tanaka A、Hirata M、Omura M、Ogata R：“p，p-DDE 和三丁基锡对 Wistar 大鼠后代的综合影响”福冈医学学报。