Clinical and experimental investigation on trace elements in normal and disturbed renal function.

正常和异常肾功能中微量元素的临床和实验研究。

• 批准号: 07807040
• 负责人: MAKITA Yuji
• 金额: $ 1.34万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07807040/
• 关键词: Trace element; Chronic renal failure; Hemodialysis; Distribution; Animal experiment; Wistar rat; 動物実験(ラット・ハムスター); 生体内動態; 尿毒症

Biologic roles and distributions of trace elements such as aluminium, arsenic, selenium, copper, zinc, chrome or manganese were investigated in hemodialysis patients and Wistar rat. Effects of serum aluminium and iron on bone turnover were studied by evaluating serum high sensitive parathyroid hormone (HS-PTH) and alkaline phosphatarse (ALP). The elevation of serum aluminium concentration induced an increase of HS-PTH and decrease of ALP.It is considered that substantial bone formation is inhibited, although HS-PTH stimulates it. On the contrary, serum iron scarcely affected bone formation and metabolism.Long term follow-up study of a hemodialysis patient with total parenteral nutrition revealed the lack of many trace elements such as copper, selenium, zinc and lead. Especially, the lack of copper or selenium was evident but clinical manifestations based on the lack of these trace elements were not observed during follow-up period (8 years). These findings might suggest the compatibility of trace elements or existence of buffer system minimizing lack of trace elements.Serum concentrations of trace elements including iron, zinc, copper and arsenic were investigated in Wistar rats. They are maintained strictly constant more than 1 year long and distributed mainly in the blood, liver, kidney and spleen.

本文研究了微量元素铝、砷、硒、铜、锌、Chrome、锰在血液透析患者和Wistar大鼠体内的生物学作用和分布。以血清高敏甲状旁腺激素（HS-PTH）和碱性磷酸酶（ALP）为指标，观察血清铝、铁对骨转换的影响。血清铝浓度升高引起HS-PTH升高和ALP降低，认为HS-PTH虽能促进骨形成，但实质上抑制了骨形成，血清铁对骨形成和骨代谢几乎无影响。特别是铜或硒缺乏明显，但在随访期间（8年）未观察到基于这些微量元素缺乏的临床表现。这些结果可能表明微量元素的兼容性或缓冲系统的存在，以减少缺乏微量元素。微量元素包括铁，锌，铜和砷在Wistar大鼠血清中的浓度进行了研究。它们严格保持恒定长达1年以上，主要分布在血液、肝、肾和脾中。

项目成果

Y.Makita: "Hemodialys patient regarded as a primary hyperoxaluria after long-term hemodialysis and renal transplantation." Fukuoka Acta Medica. 86. 121-125 (1995)

Y.Makita：“血液透析患者在长期血液透析和肾移植后被认为是原发性高草酸尿症。”

Y.Romero: "Effects of p-p-DDE on male reproductive organs in peripubertal Wistar rats following a single intraperitoneal injection" Fukuoka Acta Medica. (in press).

Y.Romero：“单次腹膜内注射后 p-p-DDE 对青春期前 Wistar 大鼠雄性生殖器官的影响”福冈医学学报。

Makita, Y.: "Hemodialysis patient regarded as a promary hyperoxaluria after long-term hemodialysis and renal transplantation." Fukuoka Acta Medica. 86. 121-125 (1995)

Makita, Y.：“血液透析患者在长期血液透析和肾移植后被视为原发性高草酸尿症。”

Romero, Y.: "Effects of p, p, -DDE on male reproductive organs in peripubertal Wistar rats following a single intraperitonealinjection." Fukuoka Acta Medica. (in press).

Romero, Y.：“单次腹膜内注射后，p、p、-DDE 对青春期前 Wistar 大鼠雄性生殖器官的影响。”