MOLECULAR MECHIANISM OF RETINAL GANGLION CELL APOTPTOSIS ANDEXPERIMENTAL GENE THERAPRYTO PREVENT THE CELL DEATH

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(1) Research on rat retinal cell death following ischemia-reperfusionWE have shown that caspase-3 plays an important role in the inner retina, whereas caspase-1 was more important in the outer retina.Horizontal cells that express p16INK4 did not show apoptotic features but were necrotic but amacrine cells that do not express the gene were apoptotic.Reactive oxygen species played an important role in retinal ischemia-reperfusion injury.(2) Research on retinal ganglion cell apoptosisRetinal ganglion cells dying by apoptosis expressed c-jun and such cell also expressed caspase-2. Caspases-1 and -3 were not expressed dying retinal ganlion cells. BDNF treatment decreased the number of apoptotic cells but expression of c-jun was not different from without the treatment. Caspase-2 expression was decreased by the treatment.(3) Experimental gene therapy for RCS ratsTreatment of RCS rats with AAV-Bcl-xL was effective to reduce the visual cell damage found in the RCS rats.