Personalized medicine for age-related macular degeneration

年龄相关性黄斑变性的个体化医疗

• 批准号: 21249084
• 负责人: YOSHIMURA Nagahisa
• 金额: $ 28.79万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21249084/
• 关键词: 眼細胞生物学; 加齢黄斑変性; 個別化医療; 遺伝子多型; テーラーメード医療

We successfully made quick detection kit for ARMS2 A69S single nucleotide polymorphism. We used this kit for our out-patients and made sure that it is practically usable for clinic. Since A69S genotype was associated with the visual outcome after photodynamic therapy but to with the visual outcome after anti-VEGF therapy, A69S genotype would determine which patients should be treated with photodynamic therapy, and which patients should be treated with anti-VEGF drug. In addition to ARMS2, we found that VEGF gene and PEDF gene were associated with the response to treatment for are-related macular degeneration.

成功制作了ARMS2 A69S单核苷酸多态性快速检测试剂盒。我们在门诊病人中使用了这套设备，并确保它在临床上实际可用。由于A69S基因型与光动力治疗后的视力结果相关，而与抗vegf治疗后的视力结果相关，因此A69S基因型将决定哪些患者应接受光动力治疗，哪些患者应接受抗vegf药物治疗。除ARMS2外，我们还发现VEGF基因和PEDF基因与角膜相关性黄斑变性治疗反应相关。

项目成果

ARMS2 (LOC387715) Variants in Japanese Patients with Exudative Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy

• DOI: 10.1016/j.ajo.2008.12.036
• 发表时间: 2009-06-01
• 期刊: AMERICAN JOURNAL OF OPHTHALMOLOGY
• 影响因子: 4.2
• 作者: Gotoh, Norimoto;Nakanishi, Hideo;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa

Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen

• DOI: 10.1111/j.1442-9071.2010.02294.x
• 发表时间: 2010-07-01
• 期刊: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
• 影响因子: 4
• 作者: Iwama, Daisuke;Tsujikawa, Akitaka;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa

ポリープ状脈絡膜血管症への光線力学療法の治療効果とARMS2 A69S多きちまはとの相関

光动力疗法治疗息肉状脉络膜血管病变的疗效及与ARMS2 A69S multi-kichimaha的相关性

• 发表时间: 2009
• 作者: 林寿子、山城健児、中西秀雄;等
• 通讯作者: 等

Haplotype Analysis of the ARMS2/HTRA1 Region in Japanese Patients with Typical Neovascular Age-Related Macular Degeneration or Polypoidal Choroidal Vasculopathy

• DOI: 10.1007/s10384-010-0865-2
• 发表时间: 2010-11-01
• 期刊: JAPANESE JOURNAL OF OPHTHALMOLOGY
• 影响因子: 2.4
• 作者: Gotoh, Norimoto;Yamashiro, Kenji;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa

Association of Elastin Gene Polymorphism to Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy

• DOI: 10.1167/iovs.11-8205
• 发表时间: 2011-11-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Yamashiro, Kenji;Mori, Keisuke;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa