Personalized medicine for age-related macular degeneration

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We successfully made quick detection kit for ARMS2 A69S single nucleotide polymorphism. We used this kit for our out-patients and made sure that it is practically usable for clinic. Since A69S genotype was associated with the visual outcome after photodynamic therapy but to with the visual outcome after anti-VEGF therapy, A69S genotype would determine which patients should be treated with photodynamic therapy, and which patients should be treated with anti-VEGF drug. In addition to ARMS2, we found that VEGF gene and PEDF gene were associated with the response to treatment for are-related macular degeneration.