An equipment for ocular hyperthermia experimental treatment of ocular tumors

眼部肿瘤实验性眼部热疗治疗设备

• 批准号: 02557067
• 负责人: YOSHIMURA Nagahisa
• 金额: $ 9.22万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02557067/
• 关键词: Hyperthermia; Malignant Melanoma; Ferromagnetic glass-ceramic; Rabiit eye; Agar phantom; Proliferative vitreoretinopathy; Retinal pigment epithelial cell; 眼内腫瘍; 家兎

This study has two objects, to make an equipment for ocular hyperthermia and to expand the diseases treated by hyperthermia.We have make two new apparatuses, a radiofrequency capacitive heating that treats a whole eye and an interstitial hyperthermia with a novel ferromagnetic glass-ceramic that heats small area of an eye. Both equipments are considered to be sage and useful for ocular hyperthermia by several examinations in the agar phantoms and rabbit eyes.In addition to tumor diseases we applied hyperthermia to proliferative vitreoretinopathy(PVR), the most serious complication of retinal detachment, that is caused by the proliferative membrane composed of retinal pigment epithelial cells(RPE), fibroblasts, and glial cells. Using a rabbit PVR model, hyperthermia reduced the occurrence of PVR in vivo. Hyperthermia, in combination with radiation, was also shown to be effective in the suppression of RPE cell growth synergistically in vitro. Therefore, hyperthermia is found to be a potential modality for the treatment of PVR as well as tumors.

本研究有两个目的，一是制作一种用于眼部热疗的设备，二是扩大热疗的治疗范围，我们制作了两种新的设备，一种是射频电容加热治疗整个眼睛，另一种是用新型铁磁玻璃陶瓷加热眼睛小区域的组织间热疗。本研究将热疗应用于视网膜脱离最严重的并发症--增殖性玻璃体视网膜病变（proliferative vitreoretinopathy，PVR），即视网膜色素上皮细胞（retinal pigment epithelial cells，RPE）、成纤维细胞和神经胶质细胞组成的增生性膜的形成。使用兔PVR模型，热疗减少体内PVR的发生。热疗与辐射的组合也显示出在体外协同抑制RPE细胞生长方面是有效的。因此，热疗被认为是治疗PVR以及肿瘤的潜在方式。

项目成果

N.Yoshimura: "Hyperthermia vedvces the occurrence of proliferative vitreoretinopathy ina rabbit model" Invertigative Opthalmolgy and Visval Science. 33. 404-409 (1992)

N.Yoshimura：“高温导致兔模型中增殖性玻璃体视网膜病变的发生”Invertigative Opthalmolgy 和 Visval Science。

M.MATSUMOTO: "Synergistic Suppression of retinal Pigment epithelial cell prolifevation by radiation and hyperthem" Investigative Ophthalmology and Visval Science.

M.MATSUMOTO：“辐射和高温对视网膜色素上皮细胞增殖的协同抑制”调查眼科和 Visval Science。

M.Matumoto et.al: "Application of ferromagnetic hyperthermia using a new glass-ceramic to rabbit eye." Invest Ophthalmol Vis Sci(suppl). 32. 1195 (1991)

M.Matumoto 等人：“使用新型微晶玻璃将铁磁热疗应用于兔眼。”

Yoshimura,N et al: "Hyperthermi a deueases the occurrence of proliferative itreo retinopathy in a rabbit model" Invest Ophthalmol Vis Sci. 33. 404-409 (1992)

Yoshimura,N 等人：“高温可减少兔子模型中增殖性 itreo 视网膜病变的发生”Invest Ophasemol Vis Sci。

M.Matsumoto: "Synergistic suppression of retinal pigment epithelial cell proliferation by radiation and hyperthermia." Investigative Ophthalmology and Visval Science(Supple). 33. 1194 (1992)

M.Matsumoto：“辐射和热疗协同抑制视网膜色素上皮细胞增殖。”