Genetical Factors Responsible For Abnormal Liver Function Tests Among Healthy Workers With Multiple Risk Factor Syndrome

患有多种危险因素综合症的健康工人肝功能检查异常的遗传因素

• 批准号: 10557045
• 负责人: OKAZAKI Isao
• 金额: $ 1.92万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10557045/
• 关键词: multiple risk factor syndrome; β3adrenergic receptor; ALDH2; liver function tests; 肝機能検査異常; 職域健康管理; β_3-adrenergic receptor; 脂肪肝; インスリン抵抗性病態; β_3-advenergic receptor

Obesity, hyperlipidemia, hypertension and hyperglycemia have been known as the atherosclerotic cardiovascular risk factors. The present study was designed to clarify the relation of aldehyde dehydrogenase 2 (ALDH2) and β3-Adrenergic Receptor (β3-AR) genes and abnormal elevation of ALT supposed to be in the process of multiple risk factor syndrome, and to clarify whether the examinations of two genes and ALT are useful for the prevention of multiple risk factor syndrome. The numbers of cases with elevated ALT increased gradually according to the accumulation of cardiovascular risk factors. Active ALDH2 was significantly more associated with the elevated ALT in the supposed process of multiple risk factor syndrome than β3-AR mutation. In normal BMI group genotypes of ALDH2 and β3-AR are associated with elevated ALT.To evaluate the genotype of ALDH2 and β3-AR may be additional and helpful way for the prediction and prevention of the multiple risk factor syndrome.

肥胖、高脂血症、高血压和高血糖被认为是动脉粥样硬化性心血管疾病的危险因素。本研究旨在阐明乙醛脱氢酶2和β3-肾上腺素能受体(β3-AR)基因与ALT异常升高之间的关系，以及这两个基因和ALT的检测是否有助于预防多危险因素综合征。ALT升高的病例数随着心血管危险因素的积累而逐渐增多。与β3-AR突变相比，在多危险因素综合征的假设过程中，激活的ALDH2与ALT升高的关联显著更大。在正常体重指数组中，ALDH2型和β3-AR基因型与ALT升高相关，对ALDH2型和β3-AR的检测可能是预测和预防多危险因素综合征的辅助手段。

项目成果

岡崎勲: "「今日の治療指針」職業性因子による疾患の動向"医学書院. 139-140 (2000)

Isao Okazaki：“当今的治疗指南：职业因素引起的疾病的趋势”Igaku Shoin 139-140 (2000)。

Murata C,Watanabe T,Okazaki I, et al: "Inactive aldehyde dehydrogenase 2 worsens glycemic control in light to moderate alcohol driners of natients with Type 2 diabetes mellitus"Alcohol and Alcoholism. (in press).

Murata C、Watanabe T、Okazaki I 等人：“2 型糖尿病患者的轻度至中度饮酒者中，失活的乙醛脱氢酶 2 会恶化血糖控制”酒精和酒精中毒。

Watanabe T,Niioka M,Okazaki I, et al: "Gene expression of interstitial collagenase in rat liver fibrosis"J.Hepatology. (In press).

Watanabe T，Niioka M，Okazaki I，等：“大鼠肝纤维化中间质胶原酶的基因表达”J.Hepatology。

Okazaki I, et al.: "Molecular mechanism of the reversibility of hepatic fibrosis"J Gastroenterol Hepatol. 15(Suppl). D26-32 (2000)

Okazaki I 等人：“肝纤维化可逆性的分子机制”J Gastroenterol Hepatol。

金子光延,小根森敬子,岡崎勲 他: "企業における海外勤務者帯同小児の健康管理支援"小児保健研究. 58. 527-531 (1999)

Mitsunobu Kaneko、Keiko Onemori、Isao Okazaki 等：“公司海外工人随行儿童的健康管理支持”儿童健康研究 58. 527-531 (1999)。