EPIDEMIOLOGICAL STUDIES ON ETIOLOGY OF LIVER FUNCTION TEST ABNORMALITIES IN WORKERS -SPECIAL REFERENCE TO HEPATITIS VIRUS TYPE C INFECTION

职工肝功能检查异常病因的流行病学研究——特别提及丙型肝炎病毒感染

• 批准号: 03454212
• 负责人: OKAZAKI Isao
• 金额: $ 3.01万
• 依托单位: TOKAI UNIVERSITY (1992)Keio University (1991)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03454212/
• 关键词: Industrial health; HCV infection; Liver disease; 健康管理; C100-3抗体; 職場の健康管理; 肝機能検査; HBVキャリア-; HCVキャリア-; アルコ-ル性肝障害

In order to investigate the etiology of the abnormalities in liver function tests among workers, 800 workers in some workplace were extensively examined. It revealed that Hepatitis B virus (HBV) carrier 7%, Hepatitis C virus antibody (c100-3 antibody) positive 11%, alcoholic liver diseases 19%, marked obesity 30%, moderate alochol drink and/or moderate obesity 34% and unknown 1% were observed in workers who showed the abnormal liver function tests but the normal daily activity of both works and usual life. 350 workers in another workplace who received the pre-retirement health check revealed that 10% of workers with abnormal liver function tests had the positive antibody against HCV, and that workers without abnormal liver function tests showed negative except few. Therefore, the indication of C100-3 test should be for workers with liver function tests. The next problem is the role of HCV infection among workers with alcoholic liver diseases at the workplace. They were very different from the patients with alcoholic liver diseases in Kurihama National Hospital. The latter revealed that the HCV infection caused alcoholic liver diseases to severer state. But the former workers were not severe be-cause their drinking habit changed to a good improvement.

为探讨作业人员肝功能异常的病因，对某工作场所800名作业人员进行了广泛调查。结果显示，肝功能异常但日常工作和生活活动正常的作业人员中，乙肝病毒携带者占7%，丙型肝炎病毒抗体(C100-3抗体)阳性占11%，酒精性肝病占19%，重度肥胖占30%，中度酒精饮料和/或中度肥胖占34%，不明原因占1%。另一工作场所350名职工退休前体检显示，肝功能异常的工人中，有10%的人丙肝抗体阳性，而肝功能正常的工人，除极少数外，其余均为阴性。因此，C100-3检测的适应证应为有肝功能检查的工人。下一个问题是丙型肝炎病毒感染在工作场所患有酒精性肝病的工人中的作用。他们与栗滨国立医院的酒精性肝病患者有很大不同。后者提示，丙型肝炎病毒感染导致酒精性肝病病情加重。但以前的工人并不严厉，因为他们的饮酒习惯改变了，有了很好的改善。

项目成果

岡崎 勲: "これからの健康管理ーがん、心臓病、肝臓病、糠尿病、ストレスの一次予防を中心にー 第2刷" 日本醫事新報社, 181 (1991)

冈崎勋：“未来的健康管理 - 关注癌症、心脏病、肝病、近距离放射治疗和压力的一级预防 - 第 2 版” 日本医疗新浦社，181 (1991)

岡崎 勲: "これからの健康管理ーがん、心臓病、肝臓病、糖尿病、ストレスの一次予防を中心にー" 日本医事新報社, 181 (1992)

冈崎勋：“未来的健康管理——关注癌症、心脏病、肝病、糖尿病和压力的一级预防”日本医疗新报社，181（1992）

岡崎 勲: "職場におけるアルコ-ル依存症" 香川県醫師会誌. 44. 32-36 (1991)

冈崎功：《工作场所的酗酒》香川县医学会杂志 44. 32-36 (1991)。

岡崎 勲: "ウィルス性肝炎の最近の動向" 日本産婦人科学会埼玉地方部会誌. 22. 82-85 (1992)

Isao Okazaki：“病毒性肝炎的最新趋势”日本妇产科学会埼玉地区分部杂志 22. 82-85 (1992)。

Okazaki,I: Ijishinnpousha Pub. Co.Primary Health Care-for the primary prevention of cancer, cardiac disease, liver disease, diabetes mellitus and stress, 2nd Edition, 197 (1993)

冈崎，我：Ijishinnpousha Pub。